Differential susceptibility 2.0: Are the same children affected by different experiences and exposures?

<jats:title>Abstract</jats:title><jats:p>Differential susceptibility theory stipulates that some children are more susceptible than others to both supportive and adverse developmental experiences/exposures. What remains unclear is whether the <jats:italic>same</jats:italic> individuals are most affected by <jats:italic>different</jats:italic> exposures (i.e., domain general vs. specific). We address this issue empirically for the first time using, for illustrative and proof-of-principle purposes, a <jats:italic>novel influence-statistics’ method</jats:italic> with data from the National Institute of Child Health and Human Development (NICHD) Study of Early Child Care. Results indicated that previously documented effects of greater quality of care on enhanced pre-academic skills and greater quantity of care on more behavior problems apply mostly to different children. Analyses validating the new method indicated, as predicted, that (a) the quantity-of-care effect applied principally to children from more socioeconomically advantaged families and that (b) being highly susceptible to both, one or neither childcare effect varied as a function of a three-gene, polygenic-plasticity score (serotonin transporter linked polymorphic region [<jats:italic>5-HTTLPR</jats:italic>], dopamine receptor D4 <jats:italic>[DRD4]</jats:italic>, brain-derived neurotrophic factor [<jats:italic>BDNF</jats:italic>]) in a dose–response manner (i.e., 2>1>0). While domain-specific findings involving child-care effects cannot be generalized to other environmental influences, the influence-statistics’ approach appears well suited for investigating the generality–specificity of environment effects, that is, of “differential, differential susceptibility.”</jats:p>