Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish
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- Da-Wei Yeh
- Immunology Research Center, National Health Research Institutes, Miaoli 35053, Taiwan;
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- Yi-Ling Liu
- Immunology Research Center, National Health Research Institutes, Miaoli 35053, Taiwan;
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- Yin-Chiu Lo
- National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 35053, Taiwan;
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- Chiou-Hwa Yuh
- Institute of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli 35053, Taiwan;
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- Guann-Yi Yu
- National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Miaoli 35053, Taiwan;
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- Jeng-Fan Lo
- Institute of Oral Biology, National Yang-Ming University, Taipei 11221, Taiwan;
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- Yunping Luo
- Department of Immunology, School of Basic Medicine, Peking Union Medical College, Beijing 100005, People’s Republic of China;
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- Rong Xiang
- School of Medicine, University of Nankai, Tianjin 300071, People’s Republic of China; and
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- Tsung-Hsien Chuang
- Immunology Research Center, National Health Research Institutes, Miaoli 35053, Taiwan;
抄録
<jats:title>Significance</jats:title><jats:p>Zebrafish Toll-like receptor (TLR) 9 (zebTLR9) and TLR21 (zebTLR21) have distinct CpG-oligodeoxynucleotide (CpG-ODN) sequence recognition profiles. The recognition profile of zebTLR9 is more like that of the TLR9s from mouse and rabbit, whereas the recognition profile of zebTLR21 is more similar to that of human TLR9 and TLR9s from domestic animals. These two zebTLRs are requlated by UNC93B1 and cooperatively mediate the immunologic and antimicrobial responses induced by CpG-ODN in zebrafish. Our findings address the molecular basis of CpG-ODN activities in zebrafish and provide information for the rational design of CpG-ODN for use as an antimicrobial agent in fishes.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 110 (51), 20711-20716, 2013-11-26
Proceedings of the National Academy of Sciences