Evolutionary developmental transcriptomics reveals a gene network module regulating interspecific diversity in plant leaf shape
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- Yasunori Ichihashi
- Department of Plant Biology,
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- José Antonio Aguilar-Martínez
- Department of Plant Biology,
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- Moran Farhi
- Department of Plant Biology,
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- Daniel H. Chitwood
- Department of Plant Biology,
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- Ravi Kumar
- Department of Plant Biology,
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- Lee V. Millon
- School of Veterinary Medicine, and
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- Jie Peng
- Department of Statistics, University of California, Davis, CA 95616; and
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- Julin N. Maloof
- Department of Plant Biology,
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- Neelima R. Sinha
- Department of Plant Biology,
説明
<jats:title>Significance</jats:title> <jats:p>Ever since Darwin’s pioneering research, a major challenge in biology has been to understand the genetic basis of morphological evolution. Utilizing the natural variation in leaf morphology between tomato and two related wild species, we identified a gene network module that leads to a dynamic rewiring of interactions in the whole leaf developmental gene regulatory network. Our work experimentally validates the hypothesis that peripheral regions of network, rather than network hubs, are more likely to contribute to evolutionary innovations. Our data also suggest that, likely due to their bottleneck location in the network, the regulation in KNOX homeobox genes was repeatedly manipulated to generate natural variation in leaf shape.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 111 (25), E2616-, 2014-06-09
Proceedings of the National Academy of Sciences
