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- Amy E. Shyer
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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- Tuomas Tallinen
- School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
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- Nandan L. Nerurkar
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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- Zhiyan Wei
- School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
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- Eun Seok Gil
- Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
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- David L. Kaplan
- Department of Biomedical Engineering, Tufts University, Medford, MA 02155, USA.
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- Clifford J. Tabin
- Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
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- L. Mahadevan
- School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA.
説明
<jats:title>Intestinal Villus Formation</jats:title> <jats:p> The intestinal villi are essential elaborations of the lining of the gut that increase the epithelial surface area for nutrient absorption. <jats:bold> Shyer <jats:italic>et al.</jats:italic> </jats:bold> (p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6155" page="212" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1238842">212</jats:related-article> , published online 29 August; see the Perspective by <jats:bold> <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6155" page="203" related-article-type="in-this-issue" vol="342" xlink:href="10.1126/science.1245288">Simons</jats:related-article> </jats:bold> ) show that in both the developing human and chick gut, the villi are formed in a step-wise progression, involving the sequential folding of the endoderm into longitudinal ridges, via a zigzag pattern, to finally form individual villi. These changes are established through the differentiation of the smooth muscle layers of the gut, restricting the expansion of the adjacent proliferating and growing endoderm and mesenchyme, generating compressive stresses that lead to the buckling and folding of the tissue. </jats:p>
収録刊行物
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- Science
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Science 342 (6155), 212-218, 2013-10-11
American Association for the Advancement of Science (AAAS)