Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia
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- Mart Toots
- Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
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- Jeong-Joong Yoon
- Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
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- Robert M. Cox
- Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
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- Michael Hart
- Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
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- Zachary M. Sticher
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- Negar Makhsous
- Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
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- Roland Plesker
- Veterinary Medicine Division, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, 63225 Langen, Germany.
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- Alec H. Barrena
- Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
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- Prabhakar G. Reddy
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- Deborah G. Mitchell
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- Ryan C. Shean
- Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
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- Gregory R. Bluemling
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- Alexander A. Kolykhalov
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- Alexander L. Greninger
- Virology Division, Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA.
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- Michael G. Natchus
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- George R. Painter
- Emory Institute for Drug Development, Emory University, Atlanta, GA 30322, USA.
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- Richard K. Plemper
- Institute for Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA.
説明
<jats:p>A next-generation, broad-spectrum, orally efficacious influenza A and B virus inhibitor is associated with a high genetic resistance barrier.</jats:p>
収録刊行物
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- Science Translational Medicine
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Science Translational Medicine 11 (515), eaax5866-, 2019-10-23
American Association for the Advancement of Science (AAAS)
