Metal–Organic‐Framework‐Derived Carbon Nanostructure Augmented Sonodynamic Cancer Therapy

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  • Xueting Pan
    Beijing Advanced Innovation Center for Soft Matter Science and Engineering Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China
  • Lixin Bai
    State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences Beijing 100190 China
  • Hui Wang
    CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
  • Qingyuan Wu
    Beijing Advanced Innovation Center for Soft Matter Science and Engineering Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China
  • Hongyu Wang
    Beijing Advanced Innovation Center for Soft Matter Science and Engineering Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China
  • Shuang Liu
    Beijing Advanced Innovation Center for Soft Matter Science and Engineering Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China
  • Bolong Xu
    Beijing Advanced Innovation Center for Soft Matter Science and Engineering Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China
  • Xinghua Shi
    CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
  • Huiyu Liu
    Beijing Advanced Innovation Center for Soft Matter Science and Engineering Bionanomaterials & Translational Engineering Laboratory State Key Laboratory of Organic‐Inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology Beijing 100029 China

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<jats:title>Abstract</jats:title><jats:p>Sonodynamic therapy (SDT) can overcome the critical issue of depth‐penetration barrier of photo‐triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal–organic‐framework (MOF)‐derived carbon nanostructure that contains porphyrin‐like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin‐like macrocycle in MOF‐derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production. The nanoparticle‐assisted cavitation process, including the visualized formation of the cavitation bubbles and microjets, is also first captured by high‐speed camera. High ROS production in PMCS under ultrasound is validated by electron spin resonance and dye measurement, followed by cellular destruction and high tumor inhibition efficiency (85%). This knowledge is important from the perspective of understanding the structure‐dependent SDT enhancement of a MOF‐derived carbon nanostructure.</jats:p>

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