Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington’s disease
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- Jeffrey M. Hausdorff
- Gerontology Division, Beth Israel Hospital, Boston 02115; and Division on Aging, Harvard Medical School, Boston 02115;
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- Susan L. Mitchell
- Gerontology Division, Beth Israel Hospital, Boston 02115; and Division on Aging, Harvard Medical School, Boston 02115;
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- Renée Firtion
- Biomedical Engineering Department, Boston University, Boston 02215;
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- C. K. Peng
- Cardiovascular Division, Beth Israel Hospital/Harvard Medical School, Boston 02215; and
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- Merit E. Cudkowicz
- Neurology Department, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114
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- Jeanne Y. Wei
- Gerontology Division, Beth Israel Hospital, Boston 02115; and Division on Aging, Harvard Medical School, Boston 02115;
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- Ary L. Goldberger
- Biomedical Engineering Department, Boston University, Boston 02215;
説明
<jats:p> Hausdorff, Jeffrey M., Susan L. Mitchell, Renée Firtion, C. K. Peng, Merit E. Cudkowicz, Jeanne Y. Wei, and Ary L. Goldberger. Altered fractal dynamics of gait: reduced stride-interval correlations with aging and Huntington’s disease. J. Appl. Physiol. 82(1): 262–269, 1997.—Fluctuations in the duration of the gait cycle (the stride interval) display fractal dynamics and long-range correlations in healthy young adults. We hypothesized that these stride-interval correlations would be altered by changes in neurological function associated with aging and certain disease states. To test this hypothesis, we compared the stride-interval time series of 1) healthy elderly subjects and young controls and of 2) subjects with Huntington’s disease and healthy controls. Using detrended fluctuation analysis, we computed α, a measure of the degree to which one stride interval is correlated with previous and subsequent intervals over different time scales. The scaling exponent α was significantly lower in elderly subjects compared with young subjects (elderly: 0.68 ± 0.14; young: 0.87 ± 0.15; P < 0.003). The scaling exponent α was also smaller in the subjects with Huntington’s disease compared with disease-free controls (Huntington’s disease: 0.60 ± 0.24; controls: 0.88 ± 0.17; P < 0.005). Moreover, α was linearly related to degree of functional impairment in subjects with Huntington’s disease ( r = 0.78, P < 0.0005). These findings demonstrate that stride-interval fluctuations are more random (i.e., less correlated) in elderly subjects and in subjects with Huntington’s disease. Abnormal alterations in the fractal properties of gait dynamics are apparently associated with changes in central nervous system control. </jats:p>
収録刊行物
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- Journal of Applied Physiology
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Journal of Applied Physiology 82 (1), 262-269, 1997-01-01
American Physiological Society
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詳細情報 詳細情報について
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- CRID
- 1360855570263356160
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- ISSN
- 15221601
- 87507587
- http://id.crossref.org/issn/87507587
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- データソース種別
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- Crossref