Dynamic genetic regulation of gene expression during cellular differentiation
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- B. J. Strober
- Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
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- R. Elorbany
- Committee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL 60637, USA.
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- K. Rhodes
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
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- N. Krishnan
- Department of Computer Science, Johns Hopkins University, Baltimore, MD 21218, USA.
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- K. Tayeb
- Department of Applied Mathematics and Statistics, Johns Hopkins University, Baltimore, MD 21218, USA.
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- A. Battle
- Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
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- Y. Gilad
- Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA.
抄録
<jats:title>Variants affect gene expression over time</jats:title> <jats:p> Genetic variation drives the spectrum of human phenotypes but in some cases has been linked to pathological conditions. Strober <jats:italic>et al.</jats:italic> set out to explore how genetic diversity regulates gene expression in cell differentiation over time. They examined expression quantitative trait loci (eQTLS)—genetic variants correlated with gene expression—in induced pluripotent stem cell lines from 19 Yoruban individuals at 16 time points during differentiation into cardiomyocytes. They identified hundreds of developmental stage–specific eQTLs. Thus, the impact of genetic variations depends on the developmental context or tissue under observation. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6447" page="1287" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aaw0040">1287</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 364 (6447), 1287-1290, 2019-06-28
American Association for the Advancement of Science (AAAS)