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- Ronny Forke
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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- Konstanze K. Gruner
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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- Kerstin E. Knott
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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- Stefan Auschill
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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- Sameer Agarwal
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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- René Martin
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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- Markus Böhl
- 2Institute of Zoology, Technical University of Dresden, Zellescher Weg 20b, 01217 Dresden, Germany
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- Sabine Richter
- 2Institute of Zoology, Technical University of Dresden, Zellescher Weg 20b, 01217 Dresden, Germany
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- Georgios Tsiavaliaris
- 3Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany
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- Roman Fedorov
- 3Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany
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- Dietmar J. Manstein
- 3Institute for Biophysical Chemistry, Hannover Medical School, 30623 Hannover, Germany
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- Herwig O. Gutzeit
- 2Institute of Zoology, Technical University of Dresden, Zellescher Weg 20b, 01217 Dresden, Germany
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- Hans-Joachim Knölker
- 1Department of Chemistry, Technical University of Dresden, Bergstrasse 66, 01069 Dresden, Germany
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説明
<jats:p>We have developed efficient synthetic routes to heterocyclic ring systems using transition metals (palladium, iron, and silver). Recent applications of this chemistry to the total synthesis of biologically active alkaloids include carbazole alkaloids (pityriazole, euchrestifoline, the antiostatins), crispine A, pentabromo- and pentachloropseudilin. The two latter alkaloids represent a novel class of myosin ATPase inhibitors that led to the discovery of a new allosteric binding site of the protein.</jats:p>
収録刊行物
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- Pure and Applied Chemistry
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Pure and Applied Chemistry 82 (11), 1975-1991, 2010-08-06
Walter de Gruyter GmbH