Fungal Beta-Glucosidases: A Bottleneck in Industrial Use of Lignocellulosic Materials
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- Annette Sørensen
- Section for Sustainable Biotechnology, Aalborg University Copenhagen, A C Meyers Vaenge 15, 2450 Copenhagen SV, Denmark
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- Mette Lübeck
- Section for Sustainable Biotechnology, Aalborg University Copenhagen, A C Meyers Vaenge 15, 2450 Copenhagen SV, Denmark
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- Peter Lübeck
- Section for Sustainable Biotechnology, Aalborg University Copenhagen, A C Meyers Vaenge 15, 2450 Copenhagen SV, Denmark
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- Birgitte Ahring
- Section for Sustainable Biotechnology, Aalborg University Copenhagen, A C Meyers Vaenge 15, 2450 Copenhagen SV, Denmark
説明
<jats:p>Profitable biomass conversion processes are highly dependent on the use of efficient enzymes for lignocellulose degradation. Among the cellulose degrading enzymes, beta-glucosidases are essential for efficient hydrolysis of cellulosic biomass as they relieve the inhibition of the cellobiohydrolases and endoglucanases by reducing cellobiose accumulation. In this review, we discuss the important role beta-glucosidases play in complex biomass hydrolysis and how they create a bottleneck in industrial use of lignocellulosic materials. An efficient beta-glucosidase facilitates hydrolysis at specified process conditions, and key points to consider in this respect are hydrolysis rate, inhibitors, and stability. Product inhibition impairing yields, thermal inactivation of enzymes, and the high cost of enzyme production are the main obstacles to commercial cellulose hydrolysis. Therefore, this sets the stage in the search for better alternatives to the currently available enzyme preparations either by improving known or screening for new beta-glucosidases.</jats:p>
収録刊行物
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- Biomolecules
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Biomolecules 3 (3), 612-631, 2013-09-03
MDPI AG
