Altered expression of CXCR3 and CCR6 and their ligands in HTLV‐1 carriers and HAM/TSP patients
-
- Houshang Rafatpanah
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
-
- Mehdi Felegari
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
-
- Mahmoud Reza Azarpazhooh
- Department of Neurology Mashhad University of Medical Sciences Mashhad Iran
-
- Rosita Vakili
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
-
- Taraneh Rajaei
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
-
- Ian Hampson
- Viral Oncology Labs Institute of Cancer Studies, University of Manchester St Mary's Hospital Oxford Road, Manchester UK
-
- Golmahossein Hassanshahi
- Molecular Medicine Research Center Rafsanjan University of Medical Sciences Rafsanjan Iran
-
- Narges Valizadeh
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
-
- Sina Gerayli
- Department of Biology Western University London Ontario, N6A 5B7 Canada
-
- Farajifard Hamid
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
-
- Shadi Zamanian
- Department of Neurology Mashhad University of Medical Sciences Mashhad Iran
-
- Farzad MollaHosseini
- Mashhad Blood Transfusion Centre Mashhad Iran
-
- Seyed Abdolrahim Rezaee
- Inflammation and Inflammatory Diseases Division Immunology Research Center Mashhad University of Medical Sciences Mashhad Iran
抄録
<jats:sec><jats:label /><jats:p>Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were measured in HAM/TSP patients, HTLV‐1 asymptomatic carriers (ACs), and healthy controls. The PVL, CCR6, and CXCR3 mRNA expression, and CXCL9 and CXCL10 protein levels were measured in all subjects. The PVL of HAM/TSP patients was higher than that of ACs (<jats:italic>P</jats:italic> = 0.02). CCR6 expression was higher in HAM/TSP patients and in ACs compared to the healthy controls (<jats:italic>P</jats:italic> = 0.005 and <jats:italic>P</jats:italic> = 0.04, respectively). A significant difference was observed in CCR6 expression when a combination of HAM/TSP patients and ACs were compared to the healthy individuals (<jats:italic>P</jats:italic> = 0.005). Furthermore, there was a significantly lower CXCR3 expression between HAM/TSP and control groups (<jats:italic>P</jats:italic> = 0.001), and between the ACs and healthy controls (<jats:italic>P</jats:italic> = 0.001). However, the increased CXCR3 expression in ACs compared to HAM/TSP patients was not significant. Furthermore, the CXCL10 protein levels in HAM/TSP patients was higher than in controls (<jats:italic>P</jats:italic> = 0.012), and CXCL9 protein levels was also higher in the HAM/TSP and ACs groups than in the controls (<jats:italic>P</jats:italic> = 0.001 and <jats:italic>P</jats:italic> = 0.004, respectively). In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV‐1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.</jats:p></jats:sec>
収録刊行物
-
- Journal of Medical Virology
-
Journal of Medical Virology 89 (8), 1461-1468, 2017-03-10
Wiley
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1360855570391291648
-
- ISSN
- 10969071
- 01466615
-
- データソース種別
-
- Crossref