Synthesis, duplex-forming ability, enzymatic stability, and in vitro antisense potency of oligonucleotides including 2′-C,4′-C-ethyleneoxy-bridged thymidine derivatives
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- Takashi Osawa
- Faculty of Pharmaceutical Sciences
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- Motoki Sawamura
- Graduate School of Pharmaceutical Sciences
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- Fumito Wada
- Graduate School of Pharmaceutical Sciences
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- Tsuyoshi Yamamoto
- Graduate School of Pharmaceutical Sciences
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- Satoshi Obika
- Graduate School of Pharmaceutical Sciences
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- Yoshiyuki Hari
- Faculty of Pharmaceutical Sciences
Abstract
<p>Three new EoDNAs were developed, and they and our previously developed methylene-EoDNAs could represent promising candidates for antisense technology.</p>
Journal
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- Organic & Biomolecular Chemistry
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Organic & Biomolecular Chemistry 15 (18), 3955-3963, 2017
Royal Society of Chemistry (RSC)
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Details 詳細情報について
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- CRID
- 1360855570525992576
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- ISSN
- 14770539
- 14770520
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- Data Source
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- Crossref