Standardization of the Modified Rodnan Skin Score for Use in Clinical Trials of Systemic Sclerosis

  • Dinesh Khanna
    University of Michigan Scleroderma Program, Ann Arbor, Michigan - USA
  • Daniel E. Furst
    University of California, Los Angeles (UCLA), Los Angeles, California - USA
  • Philip J. Clements
    University of California, Los Angeles (UCLA), Los Angeles, California - USA
  • Yannick Allanore
    Paris Descartes University, Rheumatology A Department, Cochin Hospital, Paris - France
  • Murray Baron
    Department of Medicine, McGill University, Division of Rheumatology, Jewish General Hospital, Montréal - Canada
  • Lazlo Czirjak
    Department of Immunology and Rheumatology, University of Pécs, Pécs - Hungary
  • Oliver Distler
    Division of Rheumatology, University Hospital Zurich, Zurich - Switzerland
  • Ivan Foeldvari
    Hamburger Zentrum für Kinder und Jugendrheumatologie, Hamburg - Germany
  • Masataka Kuwana
    Department of Allergy and Rheumatology, Nippon Medical School Graduate School of Medicine, Tokyo - Japan
  • Marco Matucci-Cerinic
    Department of Experimental and Clinical Medicine, Division of Rheumatology AOUC, University of Florence, Florence - Italy
  • Maureen Mayes
    University of Texas McGovern Medical School, Houston, Texas - USA
  • Thomas Medsger
    University of Pittsburgh, Pittsburgh, Pennsylvania - USA
  • Peter A. Merkel
    University of Pennsylvania, Philadelphia, Pennsylvania - USA
  • Janet E. Pope
    Deparment of Medicine, University of Western Ontario, London, Ontario - Canada
  • James R. Seibold
    Scleroderma Research Consultants LLC, Litchfield, Connecticut - USA
  • Virginia Steen
    Georgetown University, Washington DC - USA
  • Wendy Stevens
    Division of Rheumatology, St. Vincent's Hospital, Melbourne - Australia
  • Christopher P. Denton
    Centre for Rheumatology, Royal Free and University College London Medical School, London - UK

説明

<jats:p> The modified Rodnan skin score (mRSS) is a measure of skin thickness and is used as a primary or secondary outcome measure in clinical trials of systemic sclerosis (scleroderma). This state-of-art review provides a historical perspective of the development of the mRSS, summarizes the performance of mRSS as an outcome measure, provides guidance on assessing mRSS, and makes recommendations for incorporation of the mRSS into clinical trials. </jats:p>

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