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- Matthew A. Lambon Ralph
- Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom; and
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- Karen Sage
- Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom; and
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- Roy W. Jones
- Research Institute for the Care of Older People, Bath BA1 3NG, United Kingdom
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- Emily J. Mayberry
- Neuroscience and Aphasia Research Unit, School of Psychological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom; and
説明
<jats:p> In his <jats:italic>Philosophical Investigations</jats:italic> , Wittgenstein famously noted that the formation of semantic representations requires more than a simple combination of verbal and nonverbal features to generate conceptually based similarities and differences. Classical and contemporary neuroscience has tended to focus upon how different neocortical regions contribute to conceptualization through the summation of modality-specific information. The additional yet critical step of computing coherent concepts has received little attention. Some computational models of semantic memory are able to generate such concepts by the addition of modality-invariant information coded in a multidimensional semantic space. By studying patients with semantic dementia, we demonstrate that this aspect of semantic memory becomes compromised following atrophy of the anterior temporal lobes and, as a result, the patients become increasingly influenced by superficial rather than conceptual similarities. </jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 107 (6), 2717-2722, 2010-01-21
Proceedings of the National Academy of Sciences
