Histamine-Release Effectors from<i>Angelica</i><i>dahurica</i>var.<i>dahurica</i>Root
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- Yoshiyuki Kimura
- 2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan
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- Hiromichi Okuda
- 2nd Department of Medical Biochemistry, School of Medicine, Ehime University, Shigenobu-cho, Onsen-gun, Ehime 791-02, Japan
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- Kimiye Baba
- 2nd Department of Pharmacognosy, Osaka University, Pharmaceutical Sciences, Nahara, Takatsuki City, Osaka 569-11 Japan
書誌事項
- 公開日
- 1997-03-01
- DOI
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- 10.1021/np960407a
- 公開者
- American Chemical Society (ACS)
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説明
Six compounds isolated from the EtOAc fraction of the dried roots of Angelica dahurica var. dahurica inhibited compound 48/80-induced histamine levels in mouse peritoneal cavity (in vivo). Bergapten, oxypeucedanin hydrate, and byakangelicin inhibited compound 48/80-induced histamine elevation at a dose of 25 mg/kg. Conversely, sec-O-acetylbyakangelicin [8-(2-acetoxy-3-hydroxy-3-methylbutoxy)-5-methoxypsoralenI enhanced compound 48/80-induced histamine elevation at a dose of 25 mg/kg, while phellopterin and oxypeucedanin had no effect.
収録刊行物
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- Journal of Natural Products
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Journal of Natural Products 60 (3), 249-251, 1997-03-01
American Chemical Society (ACS)