Function of the<scp>SIRT</scp>3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease
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- Aneesa Ansari
- Department of Genetic Engineering and Biotechnology Jessore University of Science and Technology Jessore 7408 Bangladesh
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- Md. Shahedur Rahman
- Department of Genetic Engineering and Biotechnology Jessore University of Science and Technology Jessore 7408 Bangladesh
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- Subbroto K. Saha
- Department of Stem Cell and Regenerative Biology Konkuk University 120 Neungdong‐Ro Seoul 05029 Korea
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- Forhad K. Saikot
- Department of Genetic Engineering and Biotechnology Jessore University of Science and Technology Jessore 7408 Bangladesh
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- Akash Deep
- Central Scientific Instruments Organisation (CSIR‐CSIO) Sector 30 C Chandigarh 160030 India
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- Ki‐Hyun Kim
- Department of Civil & Environmental Engineering Hanyang University 222 Wangsimni‐Ro Seoul 04763 Korea
書誌事項
- 公開日
- 2016-09-29
- 権利情報
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- http://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1111/acel.12538
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Summary</jats:title><jats:p>In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members,<jats:styled-content style="fixed-case">SIRT</jats:styled-content>3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance.<jats:styled-content style="fixed-case">SIRT</jats:styled-content>3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes.<jats:styled-content style="fixed-case">SIRT</jats:styled-content>3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of<jats:styled-content style="fixed-case">SIRT</jats:styled-content>3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.</jats:p>
収録刊行物
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- Aging Cell
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Aging Cell 16 (1), 4-16, 2016-09-29
Wiley