Independent Association Between Plasma Leptin and C-Reactive Protein in Healthy Humans

DOI Web Site 被引用文献4件
  • Abu S.M. Shamsuzzaman
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Mikolaj Winnicki
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Robert Wolk
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Anna Svatikova
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Bradley G. Phillips
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Diane E. Davison
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Peter B. Berger
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).
  • Virend K. Somers
    From the Division of Cardiovascular Disease, Mayo Clinic, Rochester, Minn (A.S.M.S., M.W., R.W., A.S., D.E.D., V.K.S.); Department of Hypertension and Diabetology, Medical University of Gdansk, Gdansk, Poland (M.W.); Division of Clinical and Administrative Pharmacy, University of Iowa, Iowa City (B.G.P.); and Duke University Medical Center and Duke Clinical Research Institute, Durham, NC (P.B.B.).

説明

<jats:p> <jats:bold> <jats:italic>Background—</jats:italic> </jats:bold> C-reactive protein (CRP) is synthesized from the liver and is regulated by cytokines, especially interleukin-6. Leptin, the adipocyte-derived protein product of the <jats:italic>ob</jats:italic> gene, is related to amount of body fat. The long form of the leptin receptor resembles cytokine receptors, which include the interleukin-6 receptor. Both leptin and CRP may be increased in women, in obesity, and in inflammation, and both have been linked to cardiovascular pathophysiological processes and increased cardiovascular risk. We tested the hypothesis that leptin is associated with CRP levels independently of the influences of gender, body mass index (BMI), waist-to-hip ratio, and other variables. </jats:p> <jats:p> <jats:bold> <jats:italic>Methods and Results—</jats:italic> </jats:bold> We studied 100 healthy volunteers (48 men, and 52 women). For all subjects, leptin was independently associated with CRP after adjustment for age, gender, BMI, waist-to-hip ratio, smoking, and alcohol consumption (F=12.39, <jats:italic>P</jats:italic> =0.0007). There was a strong and significant positive relationship between leptin and CRP in both women ( <jats:italic>R</jats:italic> =0.61, <jats:italic>P</jats:italic> <0.0001) and men ( <jats:italic>R</jats:italic> =0.55, <jats:italic>P</jats:italic> <0.0001) considered separately. The association between leptin and CRP was significant even after adjustment for age, BMI, waist-to-hip ratio, smoking, and alcohol consumption in women (F=7.13, <jats:italic>P</jats:italic> =0.01) and men (F=5.69, <jats:italic>P</jats:italic> =0.02). When only subjects with BMI <25 kg/m <jats:sup>2</jats:sup> were considered (n=47), CRP was not linked to BMI ( <jats:italic>R</jats:italic> =0.02, <jats:italic>P</jats:italic> =0.96), but a significant association between leptin and CRP was still evident ( <jats:italic>R</jats:italic> =0.55, <jats:italic>P</jats:italic> <0.0001). </jats:p> <jats:p> <jats:bold> <jats:italic>Conclusions—</jats:italic> </jats:bold> Leptin and CRP levels are independently associated in normal humans, providing further evidence linking metabolic and inflammatory cardiovascular disease mechanisms. </jats:p>

収録刊行物

  • Circulation

    Circulation 109 (18), 2181-2185, 2004-05-11

    Ovid Technologies (Wolters Kluwer Health)

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