THE LEPTOTENE-ZYGOTENE TRANSITION OF MEIOSIS

  • D. Zickler
    Institut de Génétique et Microbiologie, Université Paris-Sud, Orsay-Cedex, 91405 France;
  • N. Kleckner
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138;

説明

<jats:p> ▪ Abstract  The leptotene/zygotene transition of meiosis, as defined by classical cytological studies, is the period when homologous chromosomes, already being discernible individualized entities, begin to be close together or touching over portions of their lengths. This period also includes the bouquet stage: Chromosome ends, which have already become integral components of the inner nuclear membrane, move into a polarized configuration, along with other nuclear envelope components. Chromosome movements, active or passive, also occur. The detailed nature of interhomologue interactions during this period, with special emphasis on the involvement of chromosome ends, and the overall role for meiosis and recombination of chromosome movement and, especially, the bouquet stage are discussed. </jats:p>

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