Class I HLA haplotypes form two schools that educate NK cells in different ways

  • Amir Horowitz
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Zakia Djaoud
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Neda Nemat-Gorgani
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Jeroen Blokhuis
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Hugo G. Hilton
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Vivien Béziat
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Karl-Johan Malmberg
    Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
  • Paul J. Norman
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Lisbeth A. Guethlein
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Peter Parham
    Departments of Structural Biology and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Description

<jats:p>Individuals heterozygous for HLA haplotypes have increased NK cell diversity because of distinct education pathways.</jats:p>

Journal

  • Science Immunology

    Science Immunology 1 (3), eaag1672-, 2016-09-16

    American Association for the Advancement of Science (AAAS)

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