Induced Fit Conformational Changes of a “Reversed Amidine” Heterocycle:  Optimized Interactions in a DNA Minor Groove Complex

  • Manoj Munde
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • Michael Lee
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • Stephen Neidle
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • Reem Arafa
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • David W. Boykin
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • Yang Liu
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • Christian Bailly
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France
  • W. David Wilson
    Contribution from the Department of Chemistry, Georgia State University, P.O. Box 4098, Atlanta, Georgia 30302-4098, Cancer Research UK Biomolecular Structure Group, The School of Pharmacy, University of London, London WC1N 1AX, UK, and INSERM U-814, IRCL, Lille 59045, France

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