The Role of the Dorsal–Lateral Prefrontal Cortex in Reward Sensitivity During Approach–Avoidance Conflict
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- Camarin E Rolle
- Department of Psychiatry and Behavioral Sciences , , Stanford, CA 94305, USA
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- Mads L Pedersen
- Department of Cognitive , Linguistic & Psychological Sciences, , Providence, RI 02912, USA
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- Noriah Johnson
- Department of Psychiatry and Behavioral Sciences , , Stanford, CA 94305, USA
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- Ken-ichi Amemori
- Institute for the Advanced Study of Human Biology (ASHBi) , Kyoto University, 606-8501 Kyoto, Japan
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- Maria Ironside
- Laureate Institute for Brain Research , 6655 South Yale Avenue, Tulsa, OK 74136, USA
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- Ann M Graybiel
- McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences , , Cambridge, MA 02139, USA
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- Diego A Pizzagalli
- McLean Hospital, Harvard Medical School , Belmont, MA 02478, USA
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- Amit Etkin
- Department of Psychiatry and Behavioral Sciences , , Stanford, CA 94305, USA
説明
<jats:title>Abstract</jats:title> <jats:p>Approach–Avoidance conflict (AAC) arises from decisions with embedded positive and negative outcomes, such that approaching leads to reward and punishment and avoiding to neither. Despite its importance, the field lacks a mechanistic understanding of which regions are driving avoidance behavior during conflict. In the current task, we utilized transcranial magnetic stimulation (TMS) and drift-diffusion modeling to investigate the role of one of the most prominent regions relevant to AAC—the dorsolateral prefrontal cortex (dlPFC). The first experiment uses in-task disruption to examine the right dlPFC’s (r-dlPFC) causal role in avoidance behavior. The second uses single TMS pulses to probe the excitability of the r-dlPFC, and downstream cortical activations, during avoidance behavior. Disrupting r-dlPFC during conflict decision-making reduced reward sensitivity. Further, r-dlPFC was engaged with a network of regions within the lateral and medial prefrontal, cingulate, and temporal cortices that associate with behavior during conflict. Together, these studies use TMS to demonstrate a role for the dlPFC in reward sensitivity during conflict and elucidate the r-dlPFC’s network of cortical regions associated with avoidance behavior. By identifying r-dlPFC’s mechanistic role in AAC behavior, contextualized within its conflict-specific downstream neural connectivity, we advance dlPFC as a potential neural target for psychiatric therapeutics.</jats:p>
収録刊行物
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- Cerebral Cortex
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Cerebral Cortex 32 (6), 1269-1285, 2021-08-31
Oxford University Press (OUP)
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詳細情報 詳細情報について
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- CRID
- 1360857593649228160
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- ISSN
- 14602199
- 10473211
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- データソース種別
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- Crossref
- KAKEN