Relationship between regional gray matter volumes and dopamine D<sub>2</sub> receptor and transporter in living human brains
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- Shin Kurose
- Department of Functional Brain Imaging National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Manabu Kubota
- Department of Functional Brain Imaging National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Keisuke Takahata
- Department of Functional Brain Imaging National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Yasuharu Yamamoto
- Department of Functional Brain Imaging National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Hironobu Fujiwara
- Department of Psychiatry Kyoto University Graduate School of Medicine Kyoto Japan
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- Yasuyuki Kimura
- Department of Clinical and Experimental Neuroimaging Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology Obu Japan
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- Hiroshi Ito
- Department of Radiology and Nuclear Medicine Fukushima Medical University Fukushima Japan
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- Hiroyoshi Takeuchi
- Department of Neuropsychiatry Keio University School of Medicine Tokyo Japan
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- Masaru Mimura
- Department of Neuropsychiatry Keio University School of Medicine Tokyo Japan
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- Tetsuya Suhara
- Department of Functional Brain Imaging National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan
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- Makoto Higuchi
- Department of Functional Brain Imaging National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology Chiba Japan
Description
<jats:title>Abstract</jats:title><jats:p>Although striatal dopamine neurotransmission is believed to be functionally linked to the formation of the corticostriatal network, there has been little evidence for this regulatory process in the human brain and its disruptions in neuropsychiatric disorders. Here, we aimed to investigate associations of striatal dopamine transporter (DAT) and D<jats:sub>2</jats:sub> receptor availabilities with gray matter (GM) volumes in healthy humans. Positron emission tomography images of D<jats:sub>2</jats:sub> receptor (<jats:italic>n</jats:italic> = 34) and DAT (<jats:italic>n</jats:italic> = 17) captured with the specific radioligands [<jats:sup>11</jats:sup>C]raclopride and [<jats:sup>18</jats:sup>F]FE‐PE2I, respectively, were acquired along with T1‐weighted magnetic resonance imaging data in our previous studies, and were re‐analyzed in this work. We quantified the binding potentials (<jats:italic>BP</jats:italic><jats:sub>ND</jats:sub>) of these radioligands in the limbic, executive, and sensorimotor functional subregions of the striatum. Correlations between the radioligand <jats:italic>BP</jats:italic><jats:sub>ND</jats:sub> and regional GM volume were then examined by voxel‐based morphometry. In line with the functional and anatomical connectivity, [<jats:sup>11</jats:sup>C]raclopride <jats:italic>BP</jats:italic><jats:sub>ND</jats:sub> in the limbic striatum was positively correlated with volumes of the uncal/parahippocampal gyrus and adjacent temporal areas. Similarly, we found positive correlations between the <jats:italic>BP</jats:italic><jats:sub>ND</jats:sub> of this radioligand in the executive striatum and volumes of the prefrontal cortices and their adjacent areas as well as between the <jats:italic>BP</jats:italic><jats:sub>ND</jats:sub> in the sensorimotor striatum and volumes of the somatosensory and supplementary motor areas. By contrast, no significant correlation was found between [<jats:sup>18</jats:sup>F]FE‐PE2I <jats:italic>BP</jats:italic><jats:sub>ND</jats:sub> and regional GM volumes. Our results suggest unique structural and functional corticostriatal associations involving D<jats:sub>2</jats:sub> receptor in healthy humans, which might be partially independent of the nigrostriatal pathway reflected by striatal DAT.</jats:p>
Journal
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- Human Brain Mapping
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Human Brain Mapping 42 (12), 4048-4058, 2021-05-20
Wiley
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Keywords
Details 詳細情報について
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- CRID
- 1360857593716968576
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- ISSN
- 10970193
- 10659471
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- Data Source
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- Crossref
- KAKEN