Shareability of antibacterial and osteoblastic‐proliferation activities of zinc‐doped hydroxyapatite nanoparticles in vitro

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  • Masanori Okada
    Department of Biological System Engineering, Graduate School of Biology‐Oriented Science and Technology Kindai University Wakayama Japan
  • Mari Oshita
    Department of Biological System Engineering, Graduate School of Biology‐Oriented Science and Technology Kindai University Wakayama Japan
  • Minami Kataoka
    Department of Biological System Engineering, Graduate School of Biology‐Oriented Science and Technology Kindai University Wakayama Japan
  • Yoshinao Azuma
    Department of Biotechnological Science, Graduate School of Biology‐Oriented Science and Technology Kindai University Wakayama Japan
  • Tsutomu Furuzono
    Department of Biological System Engineering, Graduate School of Biology‐Oriented Science and Technology Kindai University Wakayama Japan

説明

<jats:title>Abstract</jats:title><jats:p>Four types of zinc (Zn)‐doped hydroxyapatite (Zn‐HAp) nanoparticles were prepared using calcium nitrate tetrahydrate as an anti‐sintering agent during calcination at 600°C for 1 hr, to prevent calcination‐induced aggregation. The Zn content of the nanopowders was determined at 0, 4.3, 9.2, and 14.7% [Zn/(Ca + Zn) × 100] using inductively coupled plasma atomic emission spectroscopic analysis. Based on X‐ray diffraction analysis, the products were shown to possess an apatite structure without other crystalline impurities. The cell parameters of Zn‐HAp nanoparticles decreased with increasing of Zn content in the HAp structures. This tendency implies that Zn ions substituted for Ca sites in the HAp crystal lattices. To investigate the biological effects of Zn‐HAp nanoparticles, cell proliferation activity of MC3T3‐E1 osteoblasts and antibacterial activity against <jats:italic>Escherichia coli</jats:italic> were evaluated in vitro. According to the results obtained, Zn‐HAp nanoparticles containing of 14.7% Zn ions was noticeable shown shareability of the conflicting activities at 0.1 mg/mL.</jats:p>

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