Porous Microneedle Patch for Electroosmosis‐Promoted Transdermal Delivery of Drugs and Vaccines

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  • Hiroya Abe
    Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 Japan
  • Kaito Sato
    Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 Japan
  • Natsumi Kimura
    Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 Japan
  • Shinya Kusama
    Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 Japan
  • Daisuke Inoue
    Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 Japan
  • Kenshi Yamasaki
    Department of Dermatology Graduate School of Medicine Tohoku University 1-1 Seiryo-machi, Aoba-ku Sendai 980-8574 Japan
  • Matsuhiko Nishizawa
    Department of Finemechanics Graduate School of Engineering Tohoku University 6-6-01 Aramaki-aza Aoba, Aoba-ku Sendai 980-8579 Japan

書誌事項

公開日
2021-10-10
資源種別
journal article
権利情報
  • http://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1002/anbr.202100066
公開者
Wiley

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説明

<jats:sec><jats:label/><jats:p>A charged porous microneedle (PMN) generates the electroosmotic flow (EOF) and promotes the through‐needle transport of molecules and particles, indicating its applicability for the EOF‐based low‐invasive transdermal delivery of drugs and vaccines. The negatively charged PMN is prepared by grafting a thin film of poly (2‐acrylamido‐2‐methylpropanesulfonic acid) (PAMPS) onto the inner wall of the microchannels of the polyglycidyl methacrylate PMN. Promoted transport from anode to cathode is observed for albumin, Au nanoparticles (15, 50 nm), and silica beads (100 nm), indicating the generation of an EOF strong enough to transport these negatively charged larger size species against their electrophoretic motion. A model antigen ovalbumin (OVA) is preloaded in the PMN, and is injected to a hydrogel and a pig skin with a higher efficiency (more than 2 times) than the conventional diffusion‐based passive release. These results successfully demonstrate the novel EOF‐based effective injection of drugs and vaccines into the skin, achieved by the newly developed charged PMN.</jats:p></jats:sec>

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