Guanidinopropyl end‐modified poly(ethylene glycol) to form highly compact plasmid <scp>DNA</scp> mono‐ion complexes by thermal treatment
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- Haibo Qiao
- Department of Applied Chemistry Tokyo Metropolitan University Tokyo Japan
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- Shoichiro Asayama
- Department of Applied Chemistry Tokyo Metropolitan University Tokyo Japan
書誌事項
- 公開日
- 2021-10-18
- 資源種別
- journal article
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/pat.5530
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>As a monocationic poly(ethylene glycol) (PEG), a guanidinopropyl end‐modified PEG (Gu‐PEG) is used to form the mono‐ion complexes (MICs) with pDNA by thermal treatment to anneal double helix structure for improvement of the MIC formation. After thermal treatment, the Gu‐PEG/pDNA MICs formed the highly compact spherical structure with diameter of ~20 nm, which was considered to be the smallest level in the field of pDNA delivery system. The resulting heated MICs, that is, hMICs, were more stable than nonheated MICs in the presence of serum proteins. Consequently, the thermal treatment of MICs is expected to be the useful method to form highly compact MICs stabilized under physiological conditions for pDNA delivery systems in vivo.</jats:p>
収録刊行物
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- Polymers for Advanced Technologies
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Polymers for Advanced Technologies 33 (2), 484-491, 2021-10-18
Wiley
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詳細情報 詳細情報について
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- CRID
- 1360857593802457344
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- DOI
- 10.1002/pat.5530
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- ISSN
- 10991581
- 10427147
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- KAKEN
- OpenAIRE
