Serum growth differentiation factor 15 predicts hepatocellular carcinoma occurrence after hepatitis C virus elimination
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- Yuta Myojin
- Suita Japan
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- Hayato Hikita
- Suita Japan
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- Yuki Tahata
- Suita Japan
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- Akira Doi
- Suita Japan
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- Seiya Kato
- Suita Japan
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- Yoichi Sasaki
- Suita Japan
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- Kumiko Shirai
- Suita Japan
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- Sadatsugu Sakane
- Suita Japan
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- Ryoko Yamada
- Suita Japan
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- Takahiro Kodama
- Suita Japan
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- Hideki Hagiwara
- Amagasaki Japan
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- Yasuharu Imai
- Ikeda Japan
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- Naoki Hiramatsu
- Sakai Japan
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- Shinji Tamura
- Minoh Japan
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- Keiji Yamamoto
- Tanabe Japan
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- Kazuyoshi Ohkawa
- Osaka Japan
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- Taizo Hijioka
- Kawachinagano Japan
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- Hiroyuki Fukui
- Yao Japan
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- Yoshinori Doi
- Osaka Japan
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- Yukinori Yamada
- Kaizuka Japan
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- Takayuki Yakushijin
- Osaka Japan
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- Eiji Mita
- Osaka Japan
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- Ryotaro Sakamori
- Suita Japan
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- Tomohide Tatsumi
- Suita Japan
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- Tetsuo Takehara
- Suita Japan
Abstract
<jats:title>Summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>After hepatitis C virus (HCV) elimination, patients should be followed up due to risk of hepatocellular carcinoma (HCC). Growth differentiation factor 15 (GDF15) is a cytokine induced by mitochondrial dysfunction or oxidative stress.</jats:p><jats:p>Aim</jats:p><jats:p>To evaluate the prognostic value of GDF15 for HCC occurrence after HCV elimination.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We measured GDF15 levels in stored serum from patients with chronic HCV infection without a history of HCC who had achieved sustained virological response with direct‐acting antiviral agents (DAAs). The patients were randomly divided into derivation (n = 964) and validation (n = 642) cohorts.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>In the derivation cohort, serum GDF15 levels were higher in those with HCC occurrence after DAA treatment than in those without. Multivariate Cox proportional hazards analysis revealed baseline GDF15 (>1350 pg/mL, HR 2.54), AFP (>5 ng/mL, HR 2.00), and the FIB‐4 index (>3.25, HR 2.69) to be independent risk factors for HCC. Scoring based on GDF15, AFP and the FIB‐4 index stratified HCC occurrence risk. In the validation cohort, the cumulative HCC occurrence rate at 3 years was 0.64%, 3.27% and 15.3% in low‐score (N = 171), medium‐score (N = 300) and high‐score (N = 166) groups, respectively. In the total cohort, scoring divided patients with a FIB‐4 index ≤3.25, whose HCC occurrence rate was 2.0% at 3 years, into medium‐score and low‐score groups with HCC occurrence rates at 3 years of 3.76% and 0.24%, respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>Serum GDF15 predicts <jats:italic>de novo</jats:italic> HCC occurrence. Scoring using GDF15, AFP, and the FIB‐4 index can predict <jats:italic>de novo</jats:italic> HCC occurrence risk after HCV elimination.</jats:p></jats:sec>
Journal
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- Alimentary Pharmacology & Therapeutics
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Alimentary Pharmacology & Therapeutics 55 (4), 422-433, 2021-11-23
Wiley
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Details 詳細情報について
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- CRID
- 1360857593810902144
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- ISSN
- 13652036
- 02692813
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- Data Source
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- Crossref
- KAKEN