Maternal immune activation in neurodevelopmental disorders

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  • Cynthia M. Solek
    Montreal Neurological Institute McGill University Montreal Quebec Canada
  • Nasr Farooqi
    Montreal Neurological Institute McGill University Montreal Quebec Canada
  • Myriam Verly
    Montreal Neurological Institute McGill University Montreal Quebec Canada
  • Tony K. Lim
    Montreal Neurological Institute McGill University Montreal Quebec Canada
  • Edward S. Ruthazer
    Montreal Neurological Institute McGill University Montreal Quebec Canada

Description

<jats:p>Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. <jats:italic>Developmental Dynamics 247:588–619, 2018</jats:italic>. © 2017 Wiley Periodicals, Inc.</jats:p>

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