Selective neuromodulation and mutual inhibition within the <scp>CA3–CA2</scp> system can prioritize sequences for replay

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  • Tristan M. Stöber
    Department of Computational Physiology Simula Research Laboratory Lysaker Norway
  • Andrew B. Lehr
    Department of Computational Physiology Simula Research Laboratory Lysaker Norway
  • Torkel Hafting
    Centre for Integrative Neuroplasticity University of Oslo Oslo Norway
  • Arvind Kumar
    Department of Computational Science and Technology KTH Royal Institute of Technology Stockholm Sweden
  • Marianne Fyhn
    Centre for Integrative Neuroplasticity University of Oslo Oslo Norway

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Description

<jats:title>Abstract</jats:title><jats:p>To make optimal use of previous experiences, important neural activity sequences must be prioritized during hippocampal replay. Integrating insights about the interplay between CA3 and CA2, we propose a conceptual framework that allows the two regions to control which sequences are reactivated. We suggest that neuromodulatory‐gated plasticity and mutual inhibition enable discrete assembly sequences in both regions to support each other while suppressing competing sequences. This perspective provides a coherent interpretation for a variety of seemingly disconnected functional properties of CA2 and paves the way for a more general understanding of CA2.</jats:p>

Journal

  • Hippocampus

    Hippocampus 30 (11), 1228-1238, 2020-09

    Wiley

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