Cancer-associated fibroblasts and their influence on tumor immunity and immunotherapy
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- Richard Lee Barrett
- University of Pennsylvania, Philadelphia, United States
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- Ellen Puré
- University of Pennsylvania, Philadelphia, United States
Description
<jats:p>Fibroblasts play an essential role in organogenesis and the integrity of tissue architecture and function. Growth in most solid tumors is dependent upon remodeling ‘stroma’, composed of cancer-associated fibroblasts (CAFs) and extracellular matrix (ECM), which plays a critical role in tumor initiation, progression, metastasis, and therapeutic resistance. Recent studies have clearly established that the potent immunosuppressive activity of stroma is a major mechanism by which stroma can promote tumor progression and confer resistance to immune-based therapies. Herein, we review recent advances in identifying the stroma-dependent mechanisms that regulate cancer-associated inflammation and antitumor immunity, in particular, the interactions between fibroblasts and immune cells. We also review the potential mechanisms by which stroma can confer resistance to immune-based therapies for solid tumors and current advancements in stroma-targeted therapies.</jats:p>
Journal
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- eLife
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eLife 9 7243-, 2020-12-28
eLife Sciences Publications, Ltd
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Details 詳細情報について
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- CRID
- 1360857595818952704
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- ISSN
- 2050084X
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- Data Source
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- Crossref