Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis

  • Benjamin Ng
    National Heart Centre Singapore, 169609 Singapore, Singapore.
  • Jinrui Dong
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Giuseppe D’Agostino
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Sivakumar Viswanathan
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Anissa A. Widjaja
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Wei-Wen Lim
    National Heart Centre Singapore, 169609 Singapore, Singapore.
  • Nicole S. J. Ko
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Jessie Tan
    National Heart Centre Singapore, 169609 Singapore, Singapore.
  • Sonia P. Chothani
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Benjamin Huang
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Chen Xie
    National Heart Centre Singapore, 169609 Singapore, Singapore.
  • Chee Jian Pua
    National Heart Centre Singapore, 169609 Singapore, Singapore.
  • Ann-Marie Chacko
    Duke–National University of Singapore Medical School, 169857 Singapore, Singapore.
  • Nuno Guimarães-Camboa
    Institute for Cardiovascular Regeneration, Goethe University Frankfurt, Frankfurt 60590, Germany.
  • Sylvia M. Evans
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
  • Adam J. Byrne
    Fibrosis Research Group, Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.
  • Toby M. Maher
    Fibrosis Research Group, Inflammation, Repair and Development Section, National Heart and Lung Institute, Imperial College, London SW7 2AZ, UK.
  • Jiurong Liang
    Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Dianhua Jiang
    Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Paul W. Noble
    Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
  • Sebastian Schafer
    National Heart Centre Singapore, 169609 Singapore, Singapore.
  • Stuart A. Cook
    National Heart Centre Singapore, 169609 Singapore, Singapore.

説明

<jats:p>Interleukin-11 is important for lung fibroblast activation in idiopathic pulmonary fibrosis, and its signaling represents a therapeutic target.</jats:p>

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