Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury
-
- Aleksandra Stamenkovic
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Kimberley A. O’Hara
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- David C. Nelson
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Thane G. Maddaford
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Andrea L. Edel
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Graham Maddaford
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Elena Dibrov
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- MohamadReza Aghanoori
- Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Lorrie A. Kirshenbaum
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Paul Fernyhough
- Department of Pharmacology and Therapeutics, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Michel Aliani
- Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
-
- Grant N. Pierce
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
-
- Amir Ravandi
- Institute of Cardiovascular Sciences, Department of Physiology and Pathophysiology, St. Boniface Hospital, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada
この論文をさがす
説明
<jats:p> Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury are potent inducers of cardiomyocyte death. Our studies have shown that OxPCs exert this effect through a ferroptotic process that can be attenuated. A better understanding of the OxPC cell death pathway can prove a novel strategy for prevention of cell death during myocardial reperfusion injury. </jats:p>
収録刊行物
-
- American Journal of Physiology-Heart and Circulatory Physiology
-
American Journal of Physiology-Heart and Circulatory Physiology 320 (3), H1170-H1184, 2021-03-01
American Physiological Society