Iron-sulfur cluster deficiency can be sensed by IRP2 and regulates iron homeostasis and sensitivity to ferroptosis independent of IRP1 and FBXL5

DOI Web Site Web Site 2 Citations
  • Erdem M. Terzi
    Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Vladislav O. Sviderskiy
    Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Samantha W. Alvarez
    Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Gabrielle C. Whiten
    Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Richard Possemato
    Department of Pathology, New York University Grossman School of Medicine, New York, NY 10016, USA.

Description

<jats:p>Iron-sulfur clusters enable cells to sense that they have the right amount of iron, and protect them from self-destruction.</jats:p>

Journal

  • Science Advances

    Science Advances 7 (22), eabg4302-, 2021-05-28

    American Association for the Advancement of Science (AAAS)

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