Cutaneous innate immune tolerance is mediated by epigenetic control of MAP2K3 by HDAC8/9
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- Yu Sawada
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
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- Teruaki Nakatsuji
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
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- Tatsuya Dokoshi
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
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- Nikhil Nitin Kulkarni
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
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- Marc C. Liggins
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
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- George Sen
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
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- Richard L. Gallo
- Department of Dermatology, University of California, San Diego, San Diego, CA, USA.
説明
<jats:p>Inhibition of HDAC8 and HDAC9 impairs keratinocyte tolerance of TLR ligand stimulation, leading to cutaneous inflammation.</jats:p>
収録刊行物
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- Science Immunology
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Science Immunology 6 (59), 2021-05-28
American Association for the Advancement of Science (AAAS)
