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Time‐Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study
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- Lisa S. Chow
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- Emily N. C. Manoogian
- Salk Institute for Biological Studies La Jolla California USA
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- Alison Alvear
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- Jason G. Fleischer
- Salk Institute for Biological Studies La Jolla California USA
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- Honoree Thor
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- Katrina Dietsche
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- Qi Wang
- Division of Biostatistics School of Public Health University of Minnesota Minneapolis Minnesota USA
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- James S. Hodges
- Division of Biostatistics School of Public Health University of Minnesota Minneapolis Minnesota USA
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- Nicholas Esch
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- Samar Malaeb
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- Tasma Harindhanavudhi
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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- K. Sreekumaran Nair
- Division of Endocrinology Mayo Clinic College of Medicine and Science Rochester Minnesota USA
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- Satchidananda Panda
- Salk Institute for Biological Studies La Jolla California USA
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- Douglas G. Mashek
- Division of Diabetes, Endocrinology, and Metabolism University of Minnesota Minneapolis Minnesota USA
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Description
<jats:sec><jats:title>Objective</jats:title><jats:p>In contrast to intentionally restricting energy intake, restricting the eating window may be an option for treating obesity. By comparing time‐restricted eating (TRE) with an unrestricted (non‐TRE) control, it was hypothesized that TRE facilitates weight loss, alters body composition, and improves metabolic measures.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Participants (17 women and 3 men; mean [SD]: 45.5 [12.1] years; BMI 34.1 [7.5] kg/m<jats:sup>2</jats:sup>) with a prolonged eating window (15.4 [0.9] hours) were randomized to TRE (<jats:italic>n</jats:italic> = 11: 8‐hour window, unrestricted eating within window) versus non‐TRE (<jats:italic>n</jats:italic> = 9: unrestricted eating) for 12 weeks. Weight, body composition (dual x‐ray absorptiometry), lipids, blood pressure, 2‐hour oral glucose tolerance, 2‐week continuous glucose monitoring, and 2‐week physical activity (actigraphy assessed) were measured during the pre‐ and end‐intervention periods.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>The TRE group significantly reduced the eating window (end‐intervention window: 9.9 [2.0] hours) compared with the non‐TRE group (end‐intervention window: 15.1 [1.1] hours) (<jats:italic>P</jats:italic> < 0.01). Compared with non‐TRE, TRE decreased the number of eating occasions, weight, lean mass, and visceral fat (all <jats:italic>P</jats:italic> ≤ 0.05). Compared with preintervention measures, the TRE group reduced the number of eating occasions (−21.9% [30.1%]) and reduced weight (−3.7% [1.8%]), fat mass (−4% [2.9%]), lean mass (−3.0% [2.7%]), and visceral fat (−11.1% [13.4%]) (all <jats:italic>P</jats:italic> ≤ 0.05). Physical activity and metabolic measures remained unchanged.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>In the setting of a randomized trial, TRE presents a simplified view of food intake that reduces weight.</jats:p></jats:sec>
Journal
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- Obesity
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Obesity 28 (5), 860-869, 2020-04-09
Wiley
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Details 詳細情報について
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- CRID
- 1360857596651907968
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- ISSN
- 1930739X
- 19307381
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- Data Source
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- Crossref