Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis

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  • Donato Santovito
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Virginia Egea
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Kiril Bidzhekov
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Lucia Natarelli
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • André Mourão
    Institute of Structural Biolology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.
  • Xavier Blanchet
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Kanin Wichapong
    Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229HX Maastricht, Netherlands.
  • Maria Aslani
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Coy Brunßen
    Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany.
  • Michael Horckmans
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Michael Hristov
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Arie Geerlof
    Institute of Structural Biolology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.
  • Esther Lutgens
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Mat J.A.P. Daemen
    Department of Medical Biochemistry and Pathology, Amsterdam University Medical Centers, Amsterdam School of Cardiovascular Sciences (ACS), 1081HZ Amsterdam, Netherlands.
  • Tilman Hackeng
    Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229HX Maastricht, Netherlands.
  • Christian Ries
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Triantafyllos Chavakis
    Institute of Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany.
  • Henning Morawietz
    Division of Vascular Endothelium and Microcirculation, Department of Medicine III, Faculty of Medicine, TU Dresden, D-01307 Dresden, Germany.
  • Ronald Naumann
    Max-Planck-Institute of Molecular Cell Biology and Genetics, D-01307 Dresden, Germany.
  • Philipp von Hundelshausen
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Sabine Steffens
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Johan Duchêne
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Remco T.A. Megens
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
  • Michael Sattler
    Institute of Structural Biolology, Helmholtz Zentrum München, D-85764 Neuherberg, Germany.
  • Christian Weber
    Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.

Description

<jats:p>Autophagy-driven nuclear transfer of miR-126-5p guided by Mex3a enables direct inhibition of caspase-3 and protects against atherosclerosis.</jats:p>

Journal

  • Science Translational Medicine

    Science Translational Medicine 12 (546), eaaz2294-, 2020-06-03

    American Association for the Advancement of Science (AAAS)

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