Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging
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- Mónika Sztretye
- Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
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- Beatrix Dienes
- Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
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- Mónika Gönczi
- Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
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- Tamás Czirják
- Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
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- László Csernoch
- Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
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- László Dux
- Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged H-6720, Hungary
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- Péter Szentesi
- Department of Physiology, Faculty of Medicine, University of Debrecen, Debrecen H-4002, Hungary
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- Anikó Keller-Pintér
- Department of Biochemistry, Faculty of Medicine, University of Szeged, Szeged H-6720, Hungary
抄録
<jats:p>Oxidative stress is characterized by an imbalance between prooxidant and antioxidant species, leading to macromolecular damage and disruption of redox signaling and cellular control. It is a hallmark of various diseases including metabolic syndrome, chronic fatigue syndrome, neurodegenerative, cardiovascular, inflammatory, and age-related diseases. Several mitochondrial defects have been considered to contribute to the development of oxidative stress and known as the major mediators of the aging process and subsequent age-associated diseases. Thus, mitochondrial-targeted antioxidants should prevent or slow down these processes and prolong longevity. This is the reason why antioxidant treatments are extensively studied and newer and newer compounds with such an effect appear. Astaxanthin, a xanthophyll carotenoid, is the most abundant carotenoid in marine organisms and is one of the most powerful natural compounds with remarkable antioxidant activity. Here, we summarize its antioxidant targets, effects, and benefits in diseases and with aging.</jats:p>
収録刊行物
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- Oxidative Medicine and Cellular Longevity
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Oxidative Medicine and Cellular Longevity 2019 1-14, 2019-11-11
Hindawi Limited