Proteolytic Inactivation of MAP-Kinase-Kinase by Anthrax Lethal Factor

DOI Web Site 被引用文献3件
  • Nicholas S. Duesbery
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Craig P. Webb
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Stephen H. Leppla
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Valery M. Gordon
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Kurt R. Klimpel
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Terry D. Copeland
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Natalie G. Ahn
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Marianne K. Oskarsson
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Kenji Fukasawa
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • Ken D. Paull
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.
  • George F. Vande Woude
    N. S. Duesbery, C. P. Webb, T. D. Copeland, M. K. Oskarsson, G. F. Vande Woude, Advanced BioScience Laboratories–Basic Research Program, National Cancer Institute–Frederick Cancer Research and Development Center, Post Office Box B, Frederick, MD 21702, USA.

抄録

<jats:p> Anthrax lethal toxin, produced by the bacterium <jats:italic>Bacillus anthracis,</jats:italic> is the major cause of death in animals infected with anthrax. One component of this toxin, lethal factor (LF), is suspected to be a metalloprotease, but no physiological substrates have been identified. Here it is shown that LF is a protease that cleaves the amino terminus of mitogen-activated protein kinase kinases 1 and 2 (MAPKK1 and MAPKK2) and that this cleavage inactivates MAPKK1 and inhibits the MAPK signal transduction pathway. The identification of a cleavage site for LF may facilitate the development of LF inhibitors. </jats:p>

収録刊行物

  • Science

    Science 280 (5364), 734-737, 1998-05

    American Association for the Advancement of Science (AAAS)

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