Pharmacokinetics/Pharmacodynamics of Vaborbactam, a Novel Beta-Lactamase Inhibitor, in Combination with Meropenem

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<jats:p> Vaborbactam is a novel beta-lactamase inhibitor with activity against important beta-lactamases, in particular, serine carbapenemases, and is currently approved in combination with meropenem as Vabomere for the treatment of complicated urinary tract infections, including pyelonephritis. This combination is highly active against Gram-negative pathogens, especially <jats:named-content content-type="genus-species">Klebsiella pneumoniae</jats:named-content> carbapenemase (KPC)-producing carbapenem-resistant <jats:named-content content-type="genus-species">Enterobacteriaceae</jats:named-content> . </jats:p>

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