Protein Tyrosine Phosphatases: Mechanisms in Cancer

DOI Web Site 2 Citations
  • Vignesh Sivaganesh
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
  • Varsha Sivaganesh
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
  • Christina Scanlon
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
  • Alexander Iskander
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
  • Salma Maher
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
  • Thư Lê
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA
  • Bela Peethambaran
    Department of Biological Sciences, University of the Sciences, 600 S 43rd St, Philadelphia, PA 19104, USA

Description

<jats:p>Protein tyrosine kinases, especially receptor tyrosine kinases, have dominated the cancer therapeutics sphere as proteins that can be inhibited to selectively target cancer. However, protein tyrosine phosphatases (PTPs) are also an emerging target. Though historically known as negative regulators of the oncogenic tyrosine kinases, PTPs are now known to be both tumor-suppressive and oncogenic. This review will highlight key protein tyrosine phosphatases that have been thoroughly investigated in various cancers. Furthermore, the different mechanisms underlying pro-cancerous and anti-cancerous PTPs will also be explored.</jats:p>

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