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- Christina D. Camell
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
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- Matthew J. Yousefzadeh
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
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- Yi Zhu
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Larissa G. P. Langhi Prata
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Matthew A. Huggins
- Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
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- Mark Pierson
- Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
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- Lei Zhang
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
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- Ryan D. O’Kelly
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
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- Tamar Pirtskhalava
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Pengcheng Xun
- Department of Epidemiology and Biostatistics, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA.
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- Keisuke Ejima
- Department of Epidemiology and Biostatistics, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA.
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- Ailing Xue
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Utkarsh Tripathi
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Jair Machado Espindola-Netto
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Nino Giorgadze
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Elizabeth J. Atkinson
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Christina L. Inman
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Kurt O. Johnson
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Stephanie H. Cholensky
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
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- Timothy W. Carlson
- Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.
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- Nathan K. LeBrasseur
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Sundeep Khosla
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- M. Gerard O’Sullivan
- Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.
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- David B. Allison
- Department of Epidemiology and Biostatistics, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA.
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- Stephen C. Jameson
- Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
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- Alexander Meves
- Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
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- Ming Li
- Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
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- Y. S. Prakash
- Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
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- Sergio E. Chiarella
- Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
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- Sara E. Hamilton
- Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
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- Tamara Tchkonia
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Laura J. Niedernhofer
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
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- James L. Kirkland
- Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
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- Paul D. Robbins
- Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
抄録
<jats:title>Senescent cells exacerbate COVID-19</jats:title> <jats:p> Cellular senescence is a state elicited in response to stress signals and is associated with a damaging secretory phenotype. The number of senescent cells increases with advanced age and this in turn drives age-related diseases. Camell <jats:italic>et al.</jats:italic> show that senescent cells have an amplified inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (see the Perspective by Cox and Lord). This response is communicated to nonsenescent cells, suppressing viral defense mechanisms and increasing the expression of viral entry proteins. In old mice infected with a SARS-CoV-2–related virus, treatment with senolytics to reduce the senolytic cell burden reduced mortality and increased antiviral antibodies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abe4832, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe4832">eabe4832</jats:related-article> ; see also abi4474, p. <jats:related-article issue="6552" page="281" related-article-type="in-this-issue" vol="373">281</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 373 (6552), eabe4832-, 2021-07-16
American Association for the Advancement of Science (AAAS)