Senolytics reduce coronavirus-related mortality in old mice

  • Christina D. Camell
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Matthew J. Yousefzadeh
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Yi Zhu
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Larissa G. P. Langhi Prata
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Matthew A. Huggins
    Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
  • Mark Pierson
    Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
  • Lei Zhang
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Ryan D. O’Kelly
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Tamar Pirtskhalava
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Pengcheng Xun
    Department of Epidemiology and Biostatistics, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA.
  • Keisuke Ejima
    Department of Epidemiology and Biostatistics, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA.
  • Ailing Xue
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Utkarsh Tripathi
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Jair Machado Espindola-Netto
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Nino Giorgadze
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Elizabeth J. Atkinson
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Christina L. Inman
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Kurt O. Johnson
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Stephanie H. Cholensky
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • Timothy W. Carlson
    Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.
  • Nathan K. LeBrasseur
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Sundeep Khosla
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • M. Gerard O’Sullivan
    Masonic Cancer Center Comparative Pathology Shared Resource, University of Minnesota, St. Paul, MN, USA.
  • David B. Allison
    Department of Epidemiology and Biostatistics, School of Public Health, Indiana University–Bloomington, Bloomington, IN, USA.
  • Stephen C. Jameson
    Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
  • Alexander Meves
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
  • Ming Li
    Department of Dermatology, Mayo Clinic, Rochester, MN, USA.
  • Y. S. Prakash
    Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
  • Sergio E. Chiarella
    Division of Allergic Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
  • Sara E. Hamilton
    Department of Laboratory Medicine and Pathology and Center of Immunology, University of Minnesota, Minneapolis, MN, USA.
  • Tamara Tchkonia
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Laura J. Niedernhofer
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
  • James L. Kirkland
    Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
  • Paul D. Robbins
    Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.

抄録

<jats:title>Senescent cells exacerbate COVID-19</jats:title> <jats:p> Cellular senescence is a state elicited in response to stress signals and is associated with a damaging secretory phenotype. The number of senescent cells increases with advanced age and this in turn drives age-related diseases. Camell <jats:italic>et al.</jats:italic> show that senescent cells have an amplified inflammatory response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (see the Perspective by Cox and Lord). This response is communicated to nonsenescent cells, suppressing viral defense mechanisms and increasing the expression of viral entry proteins. In old mice infected with a SARS-CoV-2–related virus, treatment with senolytics to reduce the senolytic cell burden reduced mortality and increased antiviral antibodies. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , abe4832, this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.abe4832">eabe4832</jats:related-article> ; see also abi4474, p. <jats:related-article issue="6552" page="281" related-article-type="in-this-issue" vol="373">281</jats:related-article> </jats:p>

収録刊行物

  • Science

    Science 373 (6552), eabe4832-, 2021-07-16

    American Association for the Advancement of Science (AAAS)

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