Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

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  • Ming-Dong Zhang
    Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden;
  • Swapnali Barde
    Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden;
  • Ting Yang
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm 171 77, Sweden;
  • Beilei Lei
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710;
  • Lars I. Eriksson
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm 171 77, Sweden;
  • Joseph P. Mathew
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710;
  • Thomas Andreska
    Institute of Clinical Neurobiology, University of Würzburg, 97078 Wuerzburg, Germany;
  • Katerina Akassoglou
    Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94158;
  • Tibor Harkany
    Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden;
  • Tomas G. M. Hökfelt
    Department of Neuroscience, Karolinska Institutet, Stockholm 171 77, Sweden;
  • Niccolò Terrando
    Department of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm 171 77, Sweden;

Description

<jats:title>Significance</jats:title> <jats:p>Orthopedic surgery sometimes causes persistent pain and, especially in the elderly, delirium and cognitive dysfunction. Using an established mouse bone-fracture model associating with memory deficits, we assessed pain behavior and expression of several molecules in sensory neurons, spinal cord, and brain. An increase in cold sensitivity and up-regulation of several injury markers, including activating transcription factor 3, the neuropeptide galanin, and growth factor brain-derived neurotrophic factor (BDNF), were observed in sensory ganglia. In the hippocampus, BDNF protein levels were increased in mossy fibers. In contrast, the Bdnf transcript was not increased in the parent granule cell bodies, and c-Fos levels were decreased, as was neurogenesis. Thus, impaired hippocampal BDNF signaling may contribute to mental deficits observed after surgery.</jats:p>

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