Two populations of self-maintaining monocyte-independent macrophages exist in adult epididymis and testis
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- Ming Wang
- Medical Research Center, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, China;
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- Yalong Yang
- Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany;
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- Dilay Cansever
- Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland;
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- Yiming Wang
- Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada;
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- Crystal Kantores
- Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada;
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- Sébastien Messiaen
- Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l’Energie Atomique/Direction de la Recherche Fondamentale/Institut de Biologie François Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses F-92265, France;
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- Delphine Moison
- Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l’Energie Atomique/Direction de la Recherche Fondamentale/Institut de Biologie François Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses F-92265, France;
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- Gabriel Livera
- Laboratory of Development of the Gonads, Unit of Genetic Stability, Stem Cells, and Radiation, UMR E008, Commissariat à l’Energie Atomique/Direction de la Recherche Fondamentale/Institut de Biologie François Jacob/Institut de Radiobiologie Cellulaire et Moléculaire, University of Paris, University Paris-Saclay, Fontenay aux Roses F-92265, France;
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- Svetoslav Chakarov
- Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) BIOPOLIS, 138648 Singapore, Singapore;
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- Tobias Weinberger
- Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, 81377 Munich, Germany;
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- Christopher Stremmel
- Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, 81377 Munich, Germany;
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- Monika Fijak
- Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany;
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- Britta Klein
- Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany;
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- Christiane Pleuger
- Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany;
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- Zhexiong Lian
- Chronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, 510006 Guangzhou, China;
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- Wentao Ma
- Chronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, 510006 Guangzhou, China;
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- Qingzhi Liu
- Chronic Disease Laboratory, Institutes for Life Sciences and School of Medicine, South China University of Technology, 510006 Guangzhou, China;
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- Kathrin Klee
- Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany;
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- Kristian Händler
- Systems Medicine, German Center for Neurodegenerative Diseases (DZNE), 53175 Bonn, Germany;
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- Thomas Ulas
- Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany;
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- Andreas Schlitzer
- Quantitative Systems Biology Life & Medical Sciences Institute, University of Bonn, Carl Troll Strasse 31, 53115 Bonn, Germany;
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- Joachim L. Schultze
- Genomics and Immunoregulation, Life & Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany;
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- Burkhard Becher
- Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland;
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- Melanie Greter
- Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland;
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- Zhaoyuan Liu
- Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China;
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- Florent Ginhoux
- Singapore Immunology Network, Agency for Science, Technology and Research (A*STAR) BIOPOLIS, 138648 Singapore, Singapore;
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- Slava Epelman
- Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 1L7, Canada;
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- Christian Schulz
- Medizinische Klinik und Poliklinik I, Ludwig-Maximilians-Universität Klinikum, Ludwig-Maximilians-Universität, 81377 Munich, Germany;
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- Andreas Meinhardt
- Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany;
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- Sudhanshu Bhushan
- Institute of Anatomy and Cell Biology, Unit of Reproductive Biology, Justus-Liebig University Giessen, 35392 Giessen, Germany;
説明
<jats:title>Significance</jats:title> <jats:p>Infection/inflammation is a major contributor to male infertility, and macrophages are likely to be key players in both pathological progression and resolution of the inflammation. We report that macrophage populations in the epididymis and testis are derived from fetal and neonatal monocytes, which are self-maintaining during adulthood. Furthermore, during inflammation, circulating monocytes recruited to the epididymis and testis give rise to inflammatory macrophages that promote tissue damage. These data are significant for our understanding of the origins and maintenance of macrophage subpopulations in both organs; our results point to a fundamental mechanism underpinning male infertility by infection and inflammation, and pave the way for the development of innovative therapeutics to treat this important and common condition.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 118 (1), 2020-12-28
Proceedings of the National Academy of Sciences
