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- Laurence de Leval
- 1Institute of Pathology, Department of Laboratory Medicine and Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland
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- Ash A. Alizadeh
- 2Division of Oncology, Department of Medicine, Stanford University, Stanford, CA
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- P. Leif Bergsagel
- 6Division of Hematology, Department of Internal Medicine, Mayo Clinic, Phoenix, AZ
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- Elias Campo
- 7Haematopathology Section, Hospital Clínic, Institut d'Investigaciones Biomèdiques August Pi I Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain
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- Andrew Davies
- 8Centre for Cancer Immunology, University of Southampton, Southampton, United Kingdom
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- Ahmet Dogan
- 9Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
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- Jude Fitzgibbon
- 10Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
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- Steven M. Horwitz
- 11Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
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- Ari M. Melnick
- 12Department of Medicine, Weill Cornell Medicine, New York, NY
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- William G. Morice
- 13Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
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- Ryan D. Morin
- 14Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
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- Bertrand Nadel
- 17Aix Marseille University, CNRS, INSERM, CIML, Marseille, France
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- Stefano A. Pileri
- 18Haematopathology Division, IRCCS, Istituto Europeo di Oncologia, IEO, Milan, Italy
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- Richard Rosenquist
- 19Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Davide Rossi
- 21Institute of Oncology Research and Oncology Institute of Southern Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland
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- Itziar Salaverria
- 22Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain
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- Christian Steidl
- 23Centre for Lymphoid Cancer, BC Cancer and University of British Columbia, Vancouver, Canada
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- Steven P. Treon
- 24Dana Farber Cancer Institute, Boston, MA
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- Andrew D. Zelenetz
- 11Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
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- Ranjana H. Advani
- 25Division of Oncology, Department of Medicine, Stanford University, Stanford, CA
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- Carl E. Allen
- 26Division of Pediatric Hematology-Oncology, Baylor College of Medicine, Houston, TX
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- Stephen M. Ansell
- 27Mayo Clinic Cancer Center, Rochester, MN
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- Wing C. Chan
- 28Department of Pathology, City of Hope National Medical Center, Duarte, CA
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- James R. Cook
- 29Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH
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- Lucy B. Cook
- 30Centre for Haematology, Imperial College London, London, United Kingdom
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- Francesco d’Amore
- 31Department of Hematology, Aarhus University Hospital, Aarhus, Denmark
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- Stefan Dirnhofer
- 32Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland
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- Martin Dreyling
- 33Department of Medicine III, LMU Hospital, Munich, Germany
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- Kieron Dunleavy
- 34Division of Hematology and Oncology, Georgetown Lombardi Comprehensive Cancer Centre, Georgetown University Hospital, Washington, DC
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- Andrew L. Feldman
- 13Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
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- Falko Fend
- 35Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany
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- Philippe Gaulard
- 36Department of Pathology, University Hospital Henri Mondor, AP-HP, Créteil, France
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- Paolo Ghia
- 38Università Vita-Salute San Raffaele and IRCCS Ospedale San Raffaele, Milan, Italy
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- John G. Gribben
- 10Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London, United Kingdom
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- Olivier Hermine
- 39Service D’hématologie, Hôpital Universitaire Necker, Université René Descartes, Assistance Publique Hôpitaux de Paris, Paris, France
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- Daniel J. Hodson
- 40Wellcome MRC Cambridge Stem Cell Institute, Cambridge Biomedical Campus, Cambridge, United Kingdom
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- Eric D. Hsi
- 42Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC
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- Giorgio Inghirami
- 43Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY
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- Elaine S. Jaffe
- 44Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
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- Kennosuke Karube
- 45Department of Pathology and Laboratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
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- Keisuke Kataoka
- 46Division of Molecular Oncology, National Cancer Center Research Institute, Toyko, Japan
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- Wolfram Klapper
- 48Hematopathology Section and Lymph Node Registry, Department of Pathology, University Hospital Schleswig-Holstein, Kiel, Germany
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- Won Seog Kim
- 49Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea
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- Rebecca L. King
- 13Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
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- Young H. Ko
- 50Department of Pathology, Cheju Halla General Hospital, Jeju, Korea
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- Ann S. LaCasce
- 24Dana Farber Cancer Institute, Boston, MA
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- Georg Lenz
- 51Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany
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- José I. Martin-Subero
- 52Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
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- Miguel A. Piris
- 53Department of Pathology, Jiménez Díaz Foundation University Hospital, CIBERONC, Madrid, Spain
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- Stefania Pittaluga
- 44Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD
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- Laura Pasqualucci
- 54Institute for Cancer Genetics, Columbia University, New York, NY
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- Leticia Quintanilla-Martinez
- 35Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany
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- Scott J. Rodig
- 57Department of Pathology, Brigham and Women’s Hospital, Boston, MA
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- Andreas Rosenwald
- 58Department of Pathology, University of Würzburg, Würzburg, Germany
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- Gilles A. Salles
- 11Lymphoma Service, Memorial Sloan Kettering Cancer Center, New York, NY
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- Jesus San-Miguel
- 59Clínica Universidad de Navarra, Navarra, Cancer Center of University of Navarra, Cima Universidad de NavarraI, Instituto de Investigacion Sanitaria de Navarra, Centro de Investigación Biomédica en Red de Céncer, Pamplona, Spain
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- Kerry J. Savage
- 23Centre for Lymphoid Cancer, BC Cancer and University of British Columbia, Vancouver, Canada
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- Laurie H. Sehn
- 23Centre for Lymphoid Cancer, BC Cancer and University of British Columbia, Vancouver, Canada
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- Gianpietro Semenzato
- 60Department of Medicine, University of Padua and Veneto Institute of Molecular Medicine, Padova, Italy
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- Louis M. Staudt
- 61Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
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- Steven H. Swerdlow
- 62Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA
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- Constantine S. Tam
- 63Alfred Hospital and Monash University, Melbourne, Australia
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- Judith Trotman
- 64Haematology Department, Concord Repatriation General Hospital, Sydney, Australia
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- Julie M. Vose
- 65Department of Internal Medicine, Division of Hematology-Oncology, University of Nebraska Medical Center, Omaha, NE
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- Oliver Weigert
- 33Department of Medicine III, LMU Hospital, Munich, Germany
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- Wyndham H. Wilson
- 61Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD
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- Jane N. Winter
- 66Feinberg School of Medicine, Northwestern University, Chicago, IL
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- Catherine J. Wu
- 24Dana Farber Cancer Institute, Boston, MA
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- Pier L. Zinzani
- 67IRCCS Azienda Ospedaliero-Universitaria di Bologna Istitudo di Ematologia “Seràgnoli” and Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale Università di Bologna, Bologna, Italy
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- Emanuele Zucca
- 21Institute of Oncology Research and Oncology Institute of Southern Switzerland, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland
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- Adam Bagg
- 68Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA
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- David W. Scott
- 23Centre for Lymphoid Cancer, BC Cancer and University of British Columbia, Vancouver, Canada
抄録
<jats:title>Abstract</jats:title><jats:p>With the introduction of large-scale molecular profiling methods and high-throughput sequencing technologies, the genomic features of most lymphoid neoplasms have been characterized at an unprecedented scale. Although the principles for the classification and diagnosis of these disorders, founded on a multidimensional definition of disease entities, have been consolidated over the past 25 years, novel genomic data have markedly enhanced our understanding of lymphomagenesis and enriched the description of disease entities at the molecular level. Yet, the current diagnosis of lymphoid tumors is largely based on morphological assessment and immunophenotyping, with only few entities being defined by genomic criteria. This paper, which accompanies the International Consensus Classification of mature lymphoid neoplasms, will address how established assays and newly developed technologies for molecular testing already complement clinical diagnoses and provide a novel lens on disease classification. More specifically, their contributions to diagnosis refinement, risk stratification, and therapy prediction will be considered for the main categories of lymphoid neoplasms. The potential of whole-genome sequencing, circulating tumor DNA analyses, single-cell analyses, and epigenetic profiling will be discussed because these will likely become important future tools for implementing precision medicine approaches in clinical decision making for patients with lymphoid malignancies.</jats:p>
収録刊行物
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- Blood
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Blood 140 (21), 2193-2227, 2022-11-24
American Society of Hematology