Allergies and COVID‐19 vaccines: An ENDA/EAACI Position paper

  • Annick Barbaud
    Sorbonne Université INSERM Institut Pierre Louis d’Epidémiologie et de Santé Publique AP‐HP.Sorbonne Université, Hôpital Tenon Département de dermatologie et allergologie Paris France
  • Lene Heise Garvey
    Allergy Clinic Copenhagen University Hospital at Gentofte Copenhagen Denmark
  • Alessandra Arcolaci
    Immunology Unit University Hospital of Verona Policlinico G.B. Rossi Verona Italy
  • Knut Brockow
    Department of Dermatology and Allergy Biederstein Faculty of Medicine Technical University of Munich Munich Germany
  • Francesca Mori
    Allergy Unit Department of Pediatrics Meyer Children’s University Hospital
  • Cristobalina Mayorga
    Allergy Clinical Unit Hospital Regional Universitario de Málaga‐Instituto de Investigación Biomédica de Málaga‐IBIMA ARADyAL, Málaga Spain
  • Patrizia Bonadonna
    Allergy Unit Verona University Hospital Verona Italy
  • Marina Atanaskovic‐Markovic
    Faculty of Medicine University of Belgrade University Children's Hospital Belgrade Serbia
  • Luis Moral
    Moral Luis. Pediatric Allergy and Respiratory Unit Alicante University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain
  • Giovanna Zanoni
    Giovanna Zanoni, Immunology Unit, Policlinico G.B. Rossi, Azienda Ospedaliera Universitaria Integrata Verona Italy
  • Mauro Pagani
    Medicine Department Medicine Ward Mantova Hospital ASST di Mantova Italy
  • Angèle Soria
    Sorbonne Université INSERM 1135 Cimi‐Paris Hôpital Tenon Assistance Publique‐Hôpitaux de Paris Departement de dermatologie et d'allergologie Paris France
  • Maja Jošt
    University Clinic of Respiratory and Allergic Diseases Golnik Golnik Slovenia
  • Jean‐Christoph Caubet
    Department of Women‐Children‐Teenagers University Hospital of Geneva Geneva Switzerland
  • Abreu Carmo
    Allergy and Clinical Immunology Unit Centro Hospitalar de Trás‐os‐Montes e Alto Douro Vila Real and Allergy and Clinical Immunology Unit Centro Hospitalar do Baixo Vouga Aveiro Portugal
  • Al‐Ahmad Mona
    Microbiology Department Faculty of Medicine Kuwait University Kuwait
  • Alberto Alvarez‐Perea
    Allergy Department Hospital General Universitario Gregorio Marañón Madrid Spain
  • Sevim Bavbek
    School of Medicine Department of Pulmonary Diseases Division of Allergy FAAAI Ankara University Ankara Turkey
  • Biagioni Benedetta
    Division of Internal Medicine, Hepatobiliary and Immunoallergic Disease IRCCS Azienda Ospedaliero‐Universitaria di Bologna Italy
  • M.Beatrice Bilo
    Department of Clinical and Molecular Sciences Università Politecnica delle Marche Ancona Italy
  • Natalia Blanca‐López
    Infanta Leonor University Hospital Madrid Spain
  • Herrera Gádor Bogas
    Allergy Research Group Instituto de Investigación Biomédica de Málaga‐IBIMA, and Allergy Unit Hospital Regional Universitario de Málaga‐HRUM Málaga Spain
  • Alessandro Buonomo
    Allergy Unit ‐ Fondazione Policlinico Gemelli IRCCS ‐ Largo Gemelli Rome Italy
  • Gianfranco Calogiuri
    Hospital Vito Fazzi Lecce Italy
  • Giulia Carli
    SOS Allergologia e Immunologia Azienda USL Toscana Centro Ospedale S. Stefano Prato Italy
  • Josefina Cernadas
    Allergy and Clinical Immunology Department Centro Hospitalar Universitário de S. João Porto and Allergy Unit Hospital Lusíadas Porto Portugal
  • Gabriele Cortellini
    Allergy Unit Departments of Internal Medicine Azienda Sanitaria della Romagna Rimini, Hospital Rimini Italy
  • Gülfem Celik
    Department of Chest Diseases Division of Immunology and allergy Ankara University School of Medicine cebeci Hospital Ankara Turkey
  • Semra Demir
    Istanbul University Istanbul Faculty of Medicine Internal Medicine Immunology and Allergic Diseases Istanbul Turkey
  • Inmaculada Doña
    Allergy Research Group Allergy Unit Hospital Regional Universitario de Málaga Instituto de Investigación Biomédica de Málaga‐IBIMA Plaza del Hospital Civil s/n Málaga Spain
  • Adile Berna Dursun
    Department of Adult Allergy Memorial Ankara Hospital Ankara Turkey
  • Bernadette Eberlein
    Faculty of Medicine Department of Dermatology and Allergy Biederstein Technical University of Munich Munich Germany
  • Emilia Faria
    Allergy and Clinical Immunology Unit Centro Hospitalar E Universitário de Coimbra Coimbra Portugal
  • Bryan Fernandes
    Barts Health NHS Trust St Bartholomew’s Hospital London UK
  • Tomaz Garcez
    Immunology Department Manchester University NHS Foundation Trust Manchester UK
  • Ignacio Garcia‐Nunez
    Hospital Quironsalud Cordoba Cordoba Spain
  • Radoslaw Gawlik
    Department of Internal Diseases, Allergology and Clinical Immunology Medical University of Silesia Katowice Poland
  • Asli Gelincik
    Istanbul University Istanbul Faculty of Medicine, Internal Medicine, Immunology and Allergic Diseases Istanbul Turkey
  • Eva Gomes
    Allergy Department Centro Hospitalar Universitário do Porto Porto Portugal
  • Jimmy H. C. Gooi
    Department of Clinical Immunology King’s College Hospital London UK
  • Martine Grosber
    Department of Dermatology Universitair Ziekenhuis Vrije Universiteit Brussel Brussel Belgium
  • Theo Gülen
    Department of Respiratory Medicine and Allergy Department of Medicine Karolinska University Hospital Huddinge Karolinska Institutet Stockholm Sweden
  • Florence Hacard
    Allergology and Clinical Immunology Department Centre Hospitalier Lyon‐Sud Pierre‐Bénite France
  • Cyrille Hoarau
    Service transversal d'allergologie et immunologie clinique CHR de Tours Tours France
  • Christer Janson
    Department of Medical Sciences Uppsala university Sweden
  • Sebastian L. Johnston
    National Heart and Lung Institute Imperial College London London UK
  • Lukas Joerg
    Division of Allergology and Clinical Immunology Department of Pneumology, Inselspital Bern University Hospital University of Bern Bern Switzerland
  • Seçil Kepil Özdemir
    Department of Chest Diseases Division of Allergy and Immunology Chest Diseases and Surgery Training and Research Hospital Izmir Turkey
  • Ludger Klimek
    Center for Rhinology and Allergology Wiesbaden Germany
  • Mitja Košnik
    University Clinic Golnik Slovenia
  • Marek L. Kowalski
    Department of Immunology and Allergy Medical University of Lodz Poland
  • Semanur Kuyucu
    Faculty of Medicine Dpt of Pediatric Allergy and Immunology Mersin University Mersin Turkey
  • Violeta Kvedariene
    Institute of Biomedical Sciences Department of Pathology Faculty of Medicine Vilnius University Institute of Clinical Medicine, Clinic of Chest diseases, Immunology and Allergology, Faculty of Medicine Vilnius Lithuania
  • Jose Julio Laguna
    Allergy Unit, Allergo‐Anaesthesia Unit Faculty of Medicine Hospital Central de la Cruz Roja Alfonso X El Sabio University Madrid Spain
  • Carla Lombardo
    Allergy Unit Trento Italy
  • Susana Marinho
    Allergy Centre Wythenshawe Hospital Manchester University NHS Foundation Trust and University of Manchester Manchester UK
  • Hans Merk
    Dohlenfeld Muelheim Germany
  • Elisa Meucci
    SOS Allergologia ed Immunologia clinica Azienda USL Toscana Centro Ospedale San Giovanni di Dio Firenze Italy
  • Martine Morisset
    Allergy Unit Angers University Hospital Angers France
  • Rosa Munoz‐Cano
    C/Villarroel Barcelona Spain
  • Francesco Murzilli
    Allergy Unit S,S, Filippo and Nicola Avezzano Italy
  • Alla Nakonechna
    Allergy and Clinical Immunology Department University of Liverpool Royal Preston Hospital Lancashire Teaching Hospitals NHS Foundation Trust UK
  • Florin‐Dan Popescu
    Department of Allergology Carol Davila University of Medicine and Pharmacy Nicolae Malaxa Clinical Hospital Bucharest Romania
  • Grzegorz Porebski
    Department of Clinical and Environmental Allergology Jagiellonian University Medical College Krakow Poland
  • Anna Radice
    SOS Allergologia ed Immunologia clinica Azienda USL Toscana Centro Ospedale San Giovanni di Dio Firenze Italy
  • Frederico S. Regateiro
    Allergy and Clinical Immunology Unit Centro Hospitalar E Universitário de Coimbra Coimbra Portugal
  • Heike Röckmann
    Department of Dermatology University Medical Centre Utrecht‐Heidelberglaan 100 Utrecht The Netherlands
  • Antonino Romano
    Oasi Research Institute‐IRCCS Troina Italy
  • Ravishankar Sargur
    Clinical Immunology and Allergy Unit Northern General Hospital Sheffield Teaching Hospitals NHS Foundation Trust Sheffield UK
  • Joaquin Sastre
    Allergy Department Fundación Jiménez Diaz Universidad Autonoma de Madrid CIBERES Instituto de Salud Carlos III Spain
  • Kathrin Scherer Hofmeier
    Department of Dermatology and Allergy Cantonal Hospital Aarau Aarau Switzerland
  • Lenka Sedláčková
    Gennet s.r.o., Allergy and Clinical Immunology Czech Republic
  • Marta Sobotkova
    Department of Immunology Motol University Hospital and 2nd Faculty of Medicine Charles University Prague Czech Republic
  • Ingrid Terreehorst
    Department of ENT AUMC Amsterdam The Netherlands
  • Regina Treudler
    Department of Dermatology, Venerology and Allergology Universitätsmedizin Leipzig Leipzig Germany
  • Jolanta Walusiak‐Skorupa
    Department of Occupational Diseases and Environmental Health Walusiak‐Skorupa Jolanta Nofer Institute of Occupational Medicine Lodz Poland
  • Bettina Wedi
    Department of Dermatology & Allergy OE6600 Comprehensive Allergy Center Hannover Medical School Hannover Germany
  • Stefan Wöhrl
    Floridsdorf Allergy Center (FAZ) Vienna Austria
  • Mihael Zidarn
    University Clinic of Respiratory and Allergic Diseases Golnik Golnik, and Internal Medicine, Faculty of Medicine University of Ljubljana Ljubljana Slovenia
  • Torsten Zuberbier
    Charité ‐ Universitätsmedizin Berlin Klinik für Dermatologie Berlin Germany
  • Ioana Agache
    Faculty of Medicine Transylvania University Brasov Romania
  • Maria J. Torres
    Allergy Unit Regional University Hospital of Malaga IBIMA‐UMA‐ARADyAL Malaga Spain

抄録

<jats:title>Abstract</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Anaphylaxis, which is rare, has been reported after COVID‐19 vaccination, but its management is not standardized.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre‐vaccination screening and management of allergic reactions to COVID‐19 vaccines, and literature was analysed.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>No death due to anaphylaxis to COVID‐19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1—anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2—anaphylaxis to oral/topical PEG containing products; 3—recurrent anaphylaxis of unknown cause; 4—suspected or confirmed allergy to any mRNA vaccine; and 5—confirmed allergy to PEG or derivatives. We recommend a prick‐to‐prick skin test with the left‐over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID‐19 vaccines and enable more people with history of allergy to be vaccinated.</jats:p></jats:sec>

収録刊行物

  • Allergy

    Allergy 77 (8), 2292-2312, 2022-03-05

    Wiley

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