Phosphorylative Inactivation of Aminoglycosidic Antibiotics by <i>Escherichia coli</i> Carrying R Factor
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- Hamao Umezawa
- National Institute of Health, Shinagawa-ku, Tokyo, Japan
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- Masanori Okanishi
- National Institute of Health, Shinagawa-ku, Tokyo, Japan
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- Shinichi Kondo
- National Institute of Health, Shinagawa-ku, Tokyo, Japan
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- Koei Hamana
- National Institute of Health, Shinagawa-ku, Tokyo, Japan
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- Ryozo Utahara
- National Institute of Health, Shinagawa-ku, Tokyo, Japan
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- Kenji Maeda
- National Institute of Health, Shinagawa-ku, Tokyo, Japan
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- Susumu Mitsuhashi
- Department of Microbiology, School of Medicine, Gumma University, Maebashi, Japan
書誌事項
- 公開日
- 1967-09-29
- DOI
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- 10.1126/science.157.3796.1559
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:p> Kanamycin and paromamine are inactivated by an enzyme solution prepared from <jats:italic>Escherichia coli</jats:italic> carrying R factor; and the 3-hydroxyl group of 6-amino-6-deoxy-D-glucose moiety of kanamycin or the 3-hydroxyl group of glucosamine moiety of paromamine is phosphorylated. These inactivated products and dihydrostreptomycin inactivated by the enzyme solution are converted to the original antibiotics by treatment with alkaline phosphatase. </jats:p>
収録刊行物
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- Science
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Science 157 (3796), 1559-1561, 1967-09-29
American Association for the Advancement of Science (AAAS)