Methamphetamine Use and Cardiovascular Disease

DOI Web Site 2 Citations
  • Christopher G. Kevil
    From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.
  • Nicholas E. Goeders
    Pharmacology, Toxicology, and Neuroscience (N.E.G.), LSU Health Sciences Center, Shreveport, LA.
  • Matthew D. Woolard
    Microbiology and Immunology (M.D.W.), LSU Health Sciences Center, Shreveport, LA.
  • Md. Shenuarin Bhuiyan
    From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.
  • Paari Dominic
    Medicine (P.D., C.L.A.), LSU Health Sciences Center, Shreveport, LA.
  • Gopi K. Kolluru
    From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.
  • Connie L. Arnold
    Medicine (P.D., C.L.A.), LSU Health Sciences Center, Shreveport, LA.
  • James G. Traylor
    From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.
  • A. Wayne Orr
    From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.

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Other Title
  • In Search of Answers

Description

<jats:p>While the opioid epidemic has garnered significant attention, the use of methamphetamines is growing worldwide independent of wealth or region. Following overdose and accidents, the leading cause of death in methamphetamine users is cardiovascular disease, because of significant effects of methamphetamine on vasoconstriction, pulmonary hypertension, atherosclerotic plaque formation, cardiac arrhythmias, and cardiomyopathy. In this review, we examine the current literature on methamphetamine-induced changes in cardiovascular health, discuss the potential mechanisms regulating these varied effects, and highlight our deficiencies in understanding how to treat methamphetamine-associated cardiovascular dysfunction.</jats:p>

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