Diaphragm plasticity in aging and disease: therapies for muscle weakness go from strength to strength
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- Sarah M. Greising
- Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota
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- Coen A. C. Ottenheijm
- Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
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- Ken D. O’Halloran
- Department of Physiology, University College Cork, Cork, Ireland
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- Esther Barreiro
- Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Health and Experimental Sciences Department, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain
抄録
<jats:p>The diaphragm is the main inspiratory muscle and is required to be highly active throughout the life span. The diaphragm muscle must be able to produce and sustain various behaviors that range from ventilatory to nonventilatory such as those required for airway maintenance and clearance. Throughout the life span various circumstances and conditions may affect the ability of the diaphragm muscle to generate requisite forces, and in turn the diaphragm muscle may undergo significant weakness and dysfunction. For example, hypoxic stress, critical illness, cancer cachexia, chronic obstructive pulmonary disorder, and age-related sarcopenia all represent conditions in which significant diaphragm muscle dysfunction exits. This perspective review article presents several interesting topics involving diaphragm plasticity in aging and disease that were presented at the International Union of Physiological Sciences Conference in 2017. This review seeks to maximize the broad and collective research impact on diaphragm muscle dysfunction in the search for transformative treatment approaches to improve the diaphragm muscle health during aging and disease.</jats:p>
収録刊行物
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- Journal of Applied Physiology
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Journal of Applied Physiology 125 (2), 243-253, 2018-08-01
American Physiological Society