Activity of Potential Alternative Treatment Agents for Stenotrophomonas maltophilia Isolates Nonsusceptible to Levofloxacin and/or Trimethoprim-Sulfamethoxazole

  • M. Biagi
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • X. Tan
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • T. Wu
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • M. Jurkovic
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • A. Vialichka
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • K. Meyer
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
  • R. E. Mendes
    JMI Laboratories, North Liberty, Iowa, USA
  • E. Wenzler
    College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA

抄録

<jats:p> <jats:named-content content-type="genus-species">Stenotrophomonas maltophilia</jats:named-content> is difficult to treat due to the production of multiple intrinsic and acquired mechanisms of resistance. Trimethoprim-sulfamethoxazole (TMP-SMZ) and the fluoroquinolones have traditionally been considered the drugs of choice but are plagued by increasing resistance and adverse drug effects. The objective of this study was to evaluate the <jats:italic>in vitro</jats:italic> activities of 12 clinically relevant antimicrobials against clinical <jats:named-content content-type="genus-species">S. maltophilia</jats:named-content> isolates nonsusceptible to levofloxacin and/or TMP-SMZ. </jats:p>

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