DNA methylation <i>versus</i> gene expression

DOI PDF 1 Citations
  • Adrian P. Bird
    MRC Mammalian Genome Unit, King’s Buildings, West Mains Road, Edinburgh, EH9 3JT, U.K.

Abstract

<jats:title>ABSTRACT</jats:title> <jats:p>Vertebrate DNA is methylated at a high proportion of cytosine residues in the sequence CpG, and it has been suggested that the distribution of methylated and non-methylated CpGs in a given cell type influences the pattern of gene expression in those cells. Since a DNA methylation pattern is normally transmitted faithfully to daughter cells via cell division, this idea suggests an origin for stable, clonally inherited patterns of gene expression. This article discusses some of the current evidence for a relationship between DNA methylation and gene expression. Although the evidence is incomplete, it appears already that the relationship is variable: transcription of some genes is repressed by the presence of 5-methylcytosine at certain CpGs, and may be controlled by methylation, while transcription of other genes is indifferent to methylation. In attempting to explain this variability it is helpful to adopt an evolutionary perspective.</jats:p>

Journal

  • Development

    Development 83 (Supplement), 31-40, 1984-11-01

    The Company of Biologists

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