Fruits and vegetables intake and gastric cancer risk: A pooled analysis within the Stomach cancer Pooling Project
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- Ana Ferro
- EPIUnit – Instituto de Saúde Pública Universidade do Porto Porto Portugal
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- Ana Rute Costa
- EPIUnit – Instituto de Saúde Pública Universidade do Porto Porto Portugal
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- Samantha Morais
- EPIUnit – Instituto de Saúde Pública Universidade do Porto Porto Portugal
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- Paola Bertuccio
- Department of Clinical Sciences and Community Health University of Milan Milan Italy
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- Matteo Rota
- Department of Clinical Sciences and Community Health University of Milan Milan Italy
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- Claudio Pelucchi
- Department of Clinical Sciences and Community Health University of Milan Milan Italy
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- Jinfu Hu
- Harbin Medical University Harbin China
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- Kenneth C. Johnson
- School of Epidemiology and Public Health, Faculty of Medicine University of Ottawa Ottawa Ontario Canada
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- Zuo‐Feng Zhang
- Department of Epidemiology UCLA Fielding School of Public Health and Jonsson, Comprehensive Cancer Center Los Angeles California
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- Domenico Palli
- Cancer Risk Factors and Life‐Style Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network, ISPRO Florence Italy
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- Monica Ferraroni
- Department of Clinical Sciences and Community Health University of Milan Milan Italy
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- Guo‐Pei Yu
- Medical Informatics Center Peking University Peking China
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- Rossella Bonzi
- Department of Clinical Sciences and Community Health University of Milan Milan Italy
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- Bárbara Peleteiro
- EPIUnit – Instituto de Saúde Pública Universidade do Porto Porto Portugal
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- Lizbeth López‐Carrillo
- Mexico National Institute of Public Health Morelos Mexico
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- Shoichiro Tsugane
- Epidemiology and Prevention Group Center for Public Health Sciences, National Cancer Center Tokyo Japan
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- Gerson Shigueaki Hamada
- Nikkei Disease Prevention Center São Paulo Brazil
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- Akihisa Hidaka
- Epidemiology and Prevention Group Center for Public Health Sciences, National Cancer Center Tokyo Japan
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- Reza Malekzadeh
- Digestive Oncology Research Center, Digestive Disease Research Institute Tehran University of Medical Sciences Tehran Iran
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- David Zaridze
- Department of Epidemiology and Prevention Russian N.N. Blokhin Cancer Research Center Moscow Russia
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- Dmitry Maximovich
- Department of Epidemiology and Prevention Russian N.N. Blokhin Cancer Research Center Moscow Russia
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- Jesus Vioque
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) Madrid Spain
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- Eva M. Navarrete‐Muñoz
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) Madrid Spain
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- Juan Alguacil
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) Madrid Spain
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- Gemma Castaño‐Vinyals
- Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP) Madrid Spain
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- Alicja Wolk
- Unit of Nutritional Epidemiology Institute of Environmental Medicine, Karolinska Institutet Stockholm Sweden
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- Niclas Håkansson
- Unit of Nutritional Epidemiology Institute of Environmental Medicine, Karolinska Institutet Stockholm Sweden
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- Raúl Ulises Hernández‐Ramírez
- Department of Biostatistics Yale School of Public Health, Yale School of Medicine New Haven Connecticut
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- Mohammadreza Pakseresht
- Digestive Oncology Research Center, Digestive Disease Research Institute Tehran University of Medical Sciences Tehran Iran
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- Mary H. Ward
- Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland
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- Farhad Pourfarzi
- Digestive Oncology Research Center, Digestive Disease Research Institute Tehran University of Medical Sciences Tehran Iran
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- Lina Mu
- Department of Epidemiology and Environmental Health, School of Public Health and Health Professions University at Buffalo Buffalo New York
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- Malaquias López‐Cervantes
- Facultad de Medicina, UNAM Coyoacán Mexico
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- Roberto Persiani
- Dipartimento Scienze Gastroenterologiche, Endocrino‐Metaboliche e Nefro‐Urologiche Fondazione Policlinico Universitario Agostino Gemelli IRCCS Roma Italy
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- Robert C. Kurtz
- Department of Medicine Memorial Sloan Kettering Cancer Centre New York New York
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- Areti Lagiou
- Department of Public and Community Health, School of Health Sciences University of West Attica Egaleo Greece
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- Pagona Lagiou
- Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine National and Kapodistrian University of Athens Athens Greece
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- Paolo Boffetta
- The Tisch Cancer Institute, Department of Hematology and Oncology Icahn School of Medicine at Mount Sinai New York New York
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- Stefania Boccia
- Sezione di Igiene, Dipartimento Universitario di Scienze della Vita e Sanità Pubblica Università Cattolica del Sacro Cuore Roma Italy
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- Eva Negri
- Department of Biomedical and Clinical Sciences University of Milan Milan Italy
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- Maria Constanza Camargo
- Division of Cancer Epidemiology and Genetics National Cancer Institute Rockville Maryland
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- Maria Paula Curado
- Centro Internacional de Pesquisa A. C. Camargo Cancer Center São Paulo Brazil
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- Carlo La Vecchia
- Department of Clinical Sciences and Community Health University of Milan Milan Italy
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- Nuno Lunet
- EPIUnit – Instituto de Saúde Pública Universidade do Porto Porto Portugal
抄録
<jats:title>Abstract</jats:title><jats:p>A low intake of fruits and vegetables is a risk factor for gastric cancer, although there is uncertainty regarding the magnitude of the associations. In our study, the relationship between fruits and vegetables intake and gastric cancer was assessed, complementing a previous work on the association betweenconsumption of citrus fruits and gastric cancer. Data from 25 studies (8456 cases and 21 133 controls) with information on fruits and/or vegetables intake were used. A two‐stage approach based on random‐effects models was used to pool study‐specific adjusted (sex, age and the main known risk factors for gastric cancer) odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Exposure‐response relations, including linear and nonlinear associations, were modeled using one‐ and two‐order fractional polynomials. Gastric cancer risk was lower for a higher intake of fruits (OR: 0.76, 95% CI: 0.64‐0.90), noncitrus fruits (OR: 0.86, 95% CI: 0.73‐1.02), vegetables (OR: 0.68, 95% CI: 0.56‐0.84), and fruits and vegetables (OR: 0.61, 95% CI: 0.49‐0.75); results were consistent across sociodemographic and lifestyles categories, as well as study characteristics. Exposure‐response analyses showed an increasingly protective effect of portions/day of fruits (OR: 0.64, 95% CI: 0.57‐0.73 for six portions), noncitrus fruits (OR: 0.71, 95% CI: 0.61‐0.83 for six portions) and vegetables (OR: 0.51, 95% CI: 0.43‐0.60 for 10 portions). A protective effect of all fruits, noncitrus fruits and vegetables was confirmed, supporting further dietary recommendations to decrease the burden of gastric cancer.</jats:p>
収録刊行物
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- International Journal of Cancer
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International Journal of Cancer 147 (11), 3090-3101, 2020-06-29
Wiley